Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10410880" target="_blank" >RIV/00216208:11110/20:10410880 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/20:00116240 RIV/00216208:11130/20:10410880 RIV/00209775:_____/20:N0000029 RIV/00159816:_____/20:00072451 a 2 dalších

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4QWFPCotN7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4QWFPCotN7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ctr.13773" target="_blank" >10.1111/ctr.13773</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Popis výsledku v původním jazyce

Introduction Heart rate slowing agents are frequently prescribed to manage heart transplant (HTx) patients with the assumption that higher heart rate is a risk factor in cardiovascular disease. Patients and Methods This prospective two-center study investigated early progression of cardiac allograft vasculopathy (CAV) in 116 HTx patients. Examinations by coronary optical coherence tomography and 24-hour ambulatory ECG monitoring were performed both at baseline (1 month after HTx) and during follow-up (12 months after HTx). Results During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area from 9.0 +/- 2.5 to 8.0 +/- 2.4 mm(2) (P &lt; .001), and progression in mean intimal thickness (IT) from 106.5 +/- 40.4 to 130.1 +/- 53.0 mu m (P &lt; .001). No significant relationship was observed between baseline and follow-up mean heart rates and IT progression (R = .02, P = .83; R = -.13, P = .18). We found a mild inverse association between beta-blocker dosage at 12 months and IT progression (R = -.20, P = .035). Conclusion Our study did not confirm a direct association between mean heart rate and progression of CAV. The role of beta blockers warrants further investigation, with our results indicating that they may play a protective role in early CAV development.

Název v anglickém jazyce

Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Popis výsledku anglicky

Introduction Heart rate slowing agents are frequently prescribed to manage heart transplant (HTx) patients with the assumption that higher heart rate is a risk factor in cardiovascular disease. Patients and Methods This prospective two-center study investigated early progression of cardiac allograft vasculopathy (CAV) in 116 HTx patients. Examinations by coronary optical coherence tomography and 24-hour ambulatory ECG monitoring were performed both at baseline (1 month after HTx) and during follow-up (12 months after HTx). Results During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area from 9.0 +/- 2.5 to 8.0 +/- 2.4 mm(2) (P &lt; .001), and progression in mean intimal thickness (IT) from 106.5 +/- 40.4 to 130.1 +/- 53.0 mu m (P &lt; .001). No significant relationship was observed between baseline and follow-up mean heart rates and IT progression (R = .02, P = .83; R = -.13, P = .18). We found a mild inverse association between beta-blocker dosage at 12 months and IT progression (R = -.20, P = .035). Conclusion Our study did not confirm a direct association between mean heart rate and progression of CAV. The role of beta blockers warrants further investigation, with our results indicating that they may play a protective role in early CAV development.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV16-27465A" target="_blank" >NV16-27465A: Sledování koronární nemoci srdečního štěpu pomocí optické koherentní tomografie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Transplantation

ISSN

0902-0063

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

e13773

Kód UT WoS článku

000506241700001

EID výsledku v databázi Scopus

2-s2.0-85077875306