Waiting time for second kidney transplantation and mortality

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083309" target="_blank" >RIV/00023001:_____/22:00083309 - isvavai.cz</a>

Výsledek na webu

<a href="https://cjasn.asnjournals.org/content/clinjasn/17/1/90.full.pdf?with-ds=yes" target="_blank" >https://cjasn.asnjournals.org/content/clinjasn/17/1/90.full.pdf?with-ds=yes</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2215/CJN.07620621" target="_blank" >10.2215/CJN.07620621</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Waiting time for second kidney transplantation and mortality

Popis výsledku v původním jazyce

Background and objectives The median kidney transplant half-life is 10-15 years. Because of the scarcity of donor organs and immunologic sensitization of candidates for retransplantation, there is a need for quantitative information on if and when a second transplantation is no longer associated with a lower risk of mortality compared with waitlisted patients treated by dialysis. Therefore, we investigated the association of time on waiting list with patient survival in patients who received a second transplantation versus remaining on the waiting list. Design, setting, participants, &amp; measurements In this retrospective study using target trial emulation, we analyzed data of 2346 patients from the Austrian Dialysis and Transplant Registry and Eurotransplant with a failed first graft, aged over 18 years, and waitlisted for a second kidney transplantation in Austria during the years 1980-2019. The differences in restricted mean survival time and hazard ratios for all-cause mortality comparing the treatment strategies &quot;retransplant&quot; versus&quot; remain waitlisted with maintenance dialysis&quot; are reported for different waiting times after first graft loss. Results Second kidney transplantation showed a longer restricted mean survival time at 10 years of follow-up compared with remaining on the waiting list (5.8 life months gained; 95% confidence interval, 0.9 to 11.1). This survival difference was diminished in patients with longer waiting time after loss of the first allograft; restricted mean survival time differences at 10 years were 8.0 (95% confidence interval, 1.9 to 14.0) and 0.1 life months gained (95%confidence interval,214.3 to 15.2) for patients with waiting time for retransplantation of &lt; 1 and 8 years, respectively. Conclusions Second kidney transplant is associated with patient survival compared with remaining waitlisted and treatment by dialysis, but the survival difference diminishes with longer waiting time.

Název v anglickém jazyce

Waiting time for second kidney transplantation and mortality

Popis výsledku anglicky

Background and objectives The median kidney transplant half-life is 10-15 years. Because of the scarcity of donor organs and immunologic sensitization of candidates for retransplantation, there is a need for quantitative information on if and when a second transplantation is no longer associated with a lower risk of mortality compared with waitlisted patients treated by dialysis. Therefore, we investigated the association of time on waiting list with patient survival in patients who received a second transplantation versus remaining on the waiting list. Design, setting, participants, &amp; measurements In this retrospective study using target trial emulation, we analyzed data of 2346 patients from the Austrian Dialysis and Transplant Registry and Eurotransplant with a failed first graft, aged over 18 years, and waitlisted for a second kidney transplantation in Austria during the years 1980-2019. The differences in restricted mean survival time and hazard ratios for all-cause mortality comparing the treatment strategies &quot;retransplant&quot; versus&quot; remain waitlisted with maintenance dialysis&quot; are reported for different waiting times after first graft loss. Results Second kidney transplantation showed a longer restricted mean survival time at 10 years of follow-up compared with remaining on the waiting list (5.8 life months gained; 95% confidence interval, 0.9 to 11.1). This survival difference was diminished in patients with longer waiting time after loss of the first allograft; restricted mean survival time differences at 10 years were 8.0 (95% confidence interval, 1.9 to 14.0) and 0.1 life months gained (95%confidence interval,214.3 to 15.2) for patients with waiting time for retransplantation of &lt; 1 and 8 years, respectively. Conclusions Second kidney transplant is associated with patient survival compared with remaining waitlisted and treatment by dialysis, but the survival difference diminishes with longer waiting time.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical journal of the American Society of Nephrology

ISSN

1555-9041

e-ISSN

1555-905X

Svazek periodika

17

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

90-97

Kód UT WoS článku

000737125800001

EID výsledku v databázi Scopus

2-s2.0-85123299803