Association between SARS-CoV-2 messenger RNA vaccines and lower infection rates in kidney ttansplant recipients a registry-based report
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083315" target="_blank" >RIV/00023001:_____/22:00083315 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.acpjournals.org/doi/epdf/10.7326/M21-2973" target="_blank" >https://www.acpjournals.org/doi/epdf/10.7326/M21-2973</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7326/M21-2973" target="_blank" >10.7326/M21-2973</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Association between SARS-CoV-2 messenger RNA vaccines and lower infection rates in kidney ttansplant recipients a registry-based report
Popis výsledku v původním jazyce
Background: The real-world protection provided by SARS-CoV-2 messenger RNA (mRNA) vaccines to kidney transplant recipients (KTRs) remains uncertain. Objective: To study the association between mRNA vaccination and SARS-CoV-2 infection rate in KTRs. Design: Retrospective observational cohort study. Setting: The Czech Republic (17 February to 16 May 2021). Patients: 2101 KTRs followed in the Department of Nephrology at the Institute for Clinical and Experimental Medicine. Measurements: Positive result for SARS-CoV-2 on polymerase chain reaction test and vaccination status of KTRs. Results: The incidence rate in the vaccinated group was 0.474 per 1000 person-days (33 cases in 69 672 days at risk). The incidence rate in the unvaccinated group was 1.370 per 1000 person-days (79 cases in 57 658 days at risk). The unadjusted incidence rate ratio (IRR; incidence rate of vaccinated/incidence rate of unvaccinated) for KTRs was 0.346 (95% CI, 0.227 to 0.514). The multivariable adjusted IRR for KTRs was 0.544 (CI, 0.324 to 0.876). Limitation: Retrospective observational design, uneven follow-up of patient groups, and different exposition to SARS-CoV-2 stemming from strong temporal trends and differences in clinical and probably behavioral characteristics. Conclusion: Vaccination of KTRs is associated with lower risk for SARS-CoV-2 infection.
Název v anglickém jazyce
Association between SARS-CoV-2 messenger RNA vaccines and lower infection rates in kidney ttansplant recipients a registry-based report
Popis výsledku anglicky
Background: The real-world protection provided by SARS-CoV-2 messenger RNA (mRNA) vaccines to kidney transplant recipients (KTRs) remains uncertain. Objective: To study the association between mRNA vaccination and SARS-CoV-2 infection rate in KTRs. Design: Retrospective observational cohort study. Setting: The Czech Republic (17 February to 16 May 2021). Patients: 2101 KTRs followed in the Department of Nephrology at the Institute for Clinical and Experimental Medicine. Measurements: Positive result for SARS-CoV-2 on polymerase chain reaction test and vaccination status of KTRs. Results: The incidence rate in the vaccinated group was 0.474 per 1000 person-days (33 cases in 69 672 days at risk). The incidence rate in the unvaccinated group was 1.370 per 1000 person-days (79 cases in 57 658 days at risk). The unadjusted incidence rate ratio (IRR; incidence rate of vaccinated/incidence rate of unvaccinated) for KTRs was 0.346 (95% CI, 0.227 to 0.514). The multivariable adjusted IRR for KTRs was 0.544 (CI, 0.324 to 0.876). Limitation: Retrospective observational design, uneven follow-up of patient groups, and different exposition to SARS-CoV-2 stemming from strong temporal trends and differences in clinical and probably behavioral characteristics. Conclusion: Vaccination of KTRs is associated with lower risk for SARS-CoV-2 infection.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30217 - Urology and nephrology
Návaznosti výsledku
Projekt
<a href="/cs/project/NU22-C-126" target="_blank" >NU22-C-126: Aspekty imunitní odpovědi a efektivita posilující dávky mRNA vakcíny proti SARS-CoV-2 u nemocných po transplantaci ledviny</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Annals of internal medicine
ISSN
0003-4819
e-ISSN
1539-3704
Svazek periodika
175
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
961-968
Kód UT WoS článku
000830679100014
EID výsledku v databázi Scopus
2-s2.0-85134720817