Global longitudinal strain and outcome after endoscopic mitral valve repair

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083396" target="_blank" >RIV/00023001:_____/22:00083396 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/ehf2.14001" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/ehf2.14001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ehf2.14001" target="_blank" >10.1002/ehf2.14001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Global longitudinal strain and outcome after endoscopic mitral valve repair

Popis výsledku v původním jazyce

Aims Identification of heart failure (HF) patients with secondary mitral regurgitation (SMR) that benefit from mitral valve (MV) repair remains challenging. We have focused on the role of left ventricular global longitudinal strain (LV-GLS) and reservoir left atrial longitudinal strain (LASr) for the prediction of long-term survival and reverse remodelling in patients with SMR undergoing endoscopic MV repair. Methods and results The study population consisted of 110 patients (age 67 +/- 11 years, 66% men) with symptomatic SMR undergoing isolated MV repair using a minimally invasive surgical approach. Speckle tracking-derived LV-GLS and LASr were assessed in apical views using vendor-independent software. Over a median of 7.7 years (IQRs 2.9-11.2), 64 patients (58%) died. Significant reverse LV (down arrow LVESVI &gt;10 mL/m(2)), LA (down arrow LAVI &gt;10 mL/m(2)) remodelling or both were observed in 43 (39%), 37 (34%) and 19 (17%) patients, respectively. LV-GLS (HR 0.68, 95% CI 0.58-0.79, P &lt; 0.001) and LASr (HR 0.93, 95% CI 0.88-0.97, P &lt; 0.01) but not LV ejection fraction (LVEF) and LA volume index (LAVi) emerged as independent predictors of all-cause mortality in Cox regression analysis. LV-GLS was the only independent predictor of LV reverse remodelling (OR 1.24, 95% CI 1.05-1.43, P &lt; 0.001) whereas LAVi and LASr were both independent predictors of LA reverse remodelling (both P &lt; 0.05). In patients with atrial fibrillation at baseline, only LASr was an independent predictor (P &lt; 0.05) of LA reverse remodelling. Conclusions In patients with SMR undergoing endoscopic MV repair, LV-GLS and LASr are independently associated with long-term survival and reverse remodelling and may be helpful in selecting SMR patients who may benefit from this procedure.

Název v anglickém jazyce

Global longitudinal strain and outcome after endoscopic mitral valve repair

Popis výsledku anglicky

Aims Identification of heart failure (HF) patients with secondary mitral regurgitation (SMR) that benefit from mitral valve (MV) repair remains challenging. We have focused on the role of left ventricular global longitudinal strain (LV-GLS) and reservoir left atrial longitudinal strain (LASr) for the prediction of long-term survival and reverse remodelling in patients with SMR undergoing endoscopic MV repair. Methods and results The study population consisted of 110 patients (age 67 +/- 11 years, 66% men) with symptomatic SMR undergoing isolated MV repair using a minimally invasive surgical approach. Speckle tracking-derived LV-GLS and LASr were assessed in apical views using vendor-independent software. Over a median of 7.7 years (IQRs 2.9-11.2), 64 patients (58%) died. Significant reverse LV (down arrow LVESVI &gt;10 mL/m(2)), LA (down arrow LAVI &gt;10 mL/m(2)) remodelling or both were observed in 43 (39%), 37 (34%) and 19 (17%) patients, respectively. LV-GLS (HR 0.68, 95% CI 0.58-0.79, P &lt; 0.001) and LASr (HR 0.93, 95% CI 0.88-0.97, P &lt; 0.01) but not LV ejection fraction (LVEF) and LA volume index (LAVi) emerged as independent predictors of all-cause mortality in Cox regression analysis. LV-GLS was the only independent predictor of LV reverse remodelling (OR 1.24, 95% CI 1.05-1.43, P &lt; 0.001) whereas LAVi and LASr were both independent predictors of LA reverse remodelling (both P &lt; 0.05). In patients with atrial fibrillation at baseline, only LASr was an independent predictor (P &lt; 0.05) of LA reverse remodelling. Conclusions In patients with SMR undergoing endoscopic MV repair, LV-GLS and LASr are independently associated with long-term survival and reverse remodelling and may be helpful in selecting SMR patients who may benefit from this procedure.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV19-02-00130" target="_blank" >NV19-02-00130: Proteomická analýza myokardu pokročilého srdečního selháni- identifikace biomarkerů podporujících klinické rozhodování</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ESC heart failure [online]

ISSN

2055-5822

e-ISSN

2055-5822

Svazek periodika

9

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

2686-2694

Kód UT WoS článku

000806626200001

EID výsledku v databázi Scopus

2-s2.0-85131295040