Links between macrophages in perivascular adipose tissue and arterial wall: a role in atherosclerosis initiation?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083480" target="_blank" >RIV/00023001:_____/22:00083480 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11120/22:43923685 RIV/00216208:11310/22:10444932
Výsledek na webu
<a href="https://www.minervamedica.it/en/getfreepdf/MWZOWW15OXkxTGwvUFBKa1pLdHFaMEh4S2hKVHI5Z2RvN3FqNHh1Rm1qNm5aS0hWdTFKVnpKV1hMOWphY0NJSA%253D%253D/R34Y2022N05A0433.pdf" target="_blank" >https://www.minervamedica.it/en/getfreepdf/MWZOWW15OXkxTGwvUFBKa1pLdHFaMEh4S2hKVHI5Z2RvN3FqNHh1Rm1qNm5aS0hWdTFKVnpKV1hMOWphY0NJSA%253D%253D/R34Y2022N05A0433.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.23736/S0392-9590.22.04916-1" target="_blank" >10.23736/S0392-9590.22.04916-1</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Links between macrophages in perivascular adipose tissue and arterial wall: a role in atherosclerosis initiation?
Popis výsledku v původním jazyce
Background: Inflammation of adipose tissue in relation to atherosclerosis is currently widely studied in patients with advanced disease. However, data regarding polarization of adipose tissue and arterial wall macrophages and their mutual link in the early stages of atherosclerosis are scarce. The main aim of this cross-sectional study was to characterize macrophage subpopulations in arterial wall and adjacent adipose tissue; and to determine links between different subpopulations in a relatively healthy population living kidney donors.Methods: The presence of cardiovascular risk factors was established in 68 living kidney donors. Macrophage polarization was analyzed by flow cytometry and confirmed by RT-PCR in samples of visceral adipose tissue, renal artery and adjacent perivascular adipose tissue collected during hand-assisted retroperitoneoscopic nephrectomy.Results: CD14+CD16+CD36high macrophages were found only in adipose tissues and were strongly positively associated with several cardiovascular risk factors. The CD14+CD16+CD36low subpopulation was positively associated with the presence of several cardiovascular risk factors to a lesser extent in all studied tissues. In contrast, the proportion of CD14+CD16-CD36low macrophages was negatively linked to several cardiovascular risk factors and increased in subjects on statin therapy. The proportion of CD14+CD16+CD36low macrophages in perivascular, not visceral adipose tissue was associated with that of both macrophage subtypes in the arterial wall, suggesting a direct link between perivascular adipose tissue and the arterial wall.Conclusions: We confirmed the association of three macrophage subtypes in adipose tissue and arterial wall to the studied cardiovascular risk factors. Macrophage polarization in perivascular, but not visceral adipose tissue was linked to macrophage polarization in the arterial wall
Název v anglickém jazyce
Links between macrophages in perivascular adipose tissue and arterial wall: a role in atherosclerosis initiation?
Popis výsledku anglicky
Background: Inflammation of adipose tissue in relation to atherosclerosis is currently widely studied in patients with advanced disease. However, data regarding polarization of adipose tissue and arterial wall macrophages and their mutual link in the early stages of atherosclerosis are scarce. The main aim of this cross-sectional study was to characterize macrophage subpopulations in arterial wall and adjacent adipose tissue; and to determine links between different subpopulations in a relatively healthy population living kidney donors.Methods: The presence of cardiovascular risk factors was established in 68 living kidney donors. Macrophage polarization was analyzed by flow cytometry and confirmed by RT-PCR in samples of visceral adipose tissue, renal artery and adjacent perivascular adipose tissue collected during hand-assisted retroperitoneoscopic nephrectomy.Results: CD14+CD16+CD36high macrophages were found only in adipose tissues and were strongly positively associated with several cardiovascular risk factors. The CD14+CD16+CD36low subpopulation was positively associated with the presence of several cardiovascular risk factors to a lesser extent in all studied tissues. In contrast, the proportion of CD14+CD16-CD36low macrophages was negatively linked to several cardiovascular risk factors and increased in subjects on statin therapy. The proportion of CD14+CD16+CD36low macrophages in perivascular, not visceral adipose tissue was associated with that of both macrophage subtypes in the arterial wall, suggesting a direct link between perivascular adipose tissue and the arterial wall.Conclusions: We confirmed the association of three macrophage subtypes in adipose tissue and arterial wall to the studied cardiovascular risk factors. Macrophage polarization in perivascular, but not visceral adipose tissue was linked to macrophage polarization in the arterial wall
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30201 - Cardiac and Cardiovascular systems
Návaznosti výsledku
Projekt
<a href="/cs/project/NU20-01-00022" target="_blank" >NU20-01-00022: Polarizace makrofágů a mastné kyseliny celulární membrány tukové tkáně</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International angiology
ISSN
0392-9590
e-ISSN
1827-1839
Svazek periodika
41
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
IT - Italská republika
Počet stran výsledku
11
Strana od-do
433-443
Kód UT WoS článku
000886634200007
EID výsledku v databázi Scopus
2-s2.0-85140415647