Eicosanoids in human heart failure : pilot study of plasma epoxyeicosatrienoic and dihydroxyeicosatrienoic acid levels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083948" target="_blank" >RIV/00023001:_____/23:00083948 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10458596 RIV/00064203:_____/23:10458596

Výsledek na webu

<a href="https://www.archivesofmedicalscience.com/pdf-159313-88417?filename=Eicosanoids%20in%20human.pdf" target="_blank" >https://www.archivesofmedicalscience.com/pdf-159313-88417?filename=Eicosanoids%20in%20human.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/aoms/159313" target="_blank" >10.5114/aoms/159313</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Eicosanoids in human heart failure : pilot study of plasma epoxyeicosatrienoic and dihydroxyeicosatrienoic acid levels

Popis výsledku v původním jazyce

Introduction: The role of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, remains unclear in human heart failure (HF). Methods: We enrolled 50 patients with HF to measure plasma 14,15-EET and 14,15-DHET levels using commercial ELISA kits and compared them with 25 age- and sex-matched controls. Results: Both of the measured eicosanoids were significantly higher in the HF group: 14,15- EET (91.3 +/- 25.7 ng/ml vs. 64.95 +/- 35.4 ng/ml) and 14,15-DHET (10.58 +/- 2.06 ng/ml vs. 9.07 +/- 1.60 ng/ml), p for both &lt; 0.001. Conclusions: We found that peripheral plasma eicosanoid (14,15-EET, 14,15- DHET) levels are raised in patients with HF compared to age- and sex-matched controls.

Název v anglickém jazyce

Eicosanoids in human heart failure : pilot study of plasma epoxyeicosatrienoic and dihydroxyeicosatrienoic acid levels

Popis výsledku anglicky

Introduction: The role of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, remains unclear in human heart failure (HF). Methods: We enrolled 50 patients with HF to measure plasma 14,15-EET and 14,15-DHET levels using commercial ELISA kits and compared them with 25 age- and sex-matched controls. Results: Both of the measured eicosanoids were significantly higher in the HF group: 14,15- EET (91.3 +/- 25.7 ng/ml vs. 64.95 +/- 35.4 ng/ml) and 14,15-DHET (10.58 +/- 2.06 ng/ml vs. 9.07 +/- 1.60 ng/ml), p for both &lt; 0.001. Conclusions: We found that peripheral plasma eicosanoid (14,15-EET, 14,15- DHET) levels are raised in patients with HF compared to age- and sex-matched controls.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of medical science

ISSN

1734-1922

e-ISSN

1896-9151

Svazek periodika

19

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

5

Strana od-do

513-517

Kód UT WoS článku

000980693500027

EID výsledku v databázi Scopus

2-s2.0-85152255693