Eicosanoids in Coronary Sinus Correlate with NT-proBNP in Heart Failure with Reduced Ejection Fraction Indicated to Resynchronization Therapy: Insights from Eicosanoids in Human Heart Failure Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085528" target="_blank" >RIV/00023001:_____/25:00085528 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/25:10494846 RIV/00064203:_____/25:10494846

Výsledek na webu

<a href="https://link.springer.com/content/pdf/10.1007/s44411-025-00031-w.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s44411-025-00031-w.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s44411-025-00031-w" target="_blank" >10.1007/s44411-025-00031-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Eicosanoids in Coronary Sinus Correlate with NT-proBNP in Heart Failure with Reduced Ejection Fraction Indicated to Resynchronization Therapy: Insights from Eicosanoids in Human Heart Failure Study

Popis výsledku v původním jazyce

IntroductionThe diagnostic potential of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, in chronic heart failure with reduced ejection fraction (HFrEF) remains unclear. The aim was to investigate levels of eicosanoids in different body compartments and their relation to natriuretic peptides.Material and methodsEleven HFrEF patients indicated to cardiac resynchronization therapy (CRT) were enrolled to measure 14,15-epoxyeicosatrienoic acid (14,15-EET), 14,15-dihydroxyicosatrienoic acid (14,15-DHET) and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels from venous, arterial, and coronary sinus (CS) blood samples.ResultsIn CS, NT-proBNP negatively correlated with plasmatic 14,15-EET (r = - 0.63, p = 0.03) and positively with the DHET/EET ratio (r = 0.73, p = 0.02). This correlation was not found in the other compartments. Plasmatic 14,15-EET nor 14,15-DHET levels in measured compartments did not differ statistically (p = 0.21, p = 0,64, respectively). In individual patients, the levels of both eicosanoids correlated across all compartments. Peripheral plasma 14,15-EET levels in controls were lower compared to HFrEF patients.ConclusionsPeripheral venous eicosanoid (14,15-EET, 14,15-DHET) levels correlate and do not differ from arterial and CS levels in patients with HFrEF indicated to CRT. In CS, NT-proBNP negatively correlates with plasmatic 14,15-EET and positively with the DHET/EET ratio, an indirect measurement of soluble epoxide hydrolase (sEH) activity, suggesting an important role of eicosanoids and sEH in HFrEF pathophysiology.

Název v anglickém jazyce

Eicosanoids in Coronary Sinus Correlate with NT-proBNP in Heart Failure with Reduced Ejection Fraction Indicated to Resynchronization Therapy: Insights from Eicosanoids in Human Heart Failure Study

Popis výsledku anglicky

IntroductionThe diagnostic potential of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, in chronic heart failure with reduced ejection fraction (HFrEF) remains unclear. The aim was to investigate levels of eicosanoids in different body compartments and their relation to natriuretic peptides.Material and methodsEleven HFrEF patients indicated to cardiac resynchronization therapy (CRT) were enrolled to measure 14,15-epoxyeicosatrienoic acid (14,15-EET), 14,15-dihydroxyicosatrienoic acid (14,15-DHET) and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels from venous, arterial, and coronary sinus (CS) blood samples.ResultsIn CS, NT-proBNP negatively correlated with plasmatic 14,15-EET (r = - 0.63, p = 0.03) and positively with the DHET/EET ratio (r = 0.73, p = 0.02). This correlation was not found in the other compartments. Plasmatic 14,15-EET nor 14,15-DHET levels in measured compartments did not differ statistically (p = 0.21, p = 0,64, respectively). In individual patients, the levels of both eicosanoids correlated across all compartments. Peripheral plasma 14,15-EET levels in controls were lower compared to HFrEF patients.ConclusionsPeripheral venous eicosanoid (14,15-EET, 14,15-DHET) levels correlate and do not differ from arterial and CS levels in patients with HFrEF indicated to CRT. In CS, NT-proBNP negatively correlates with plasmatic 14,15-EET and positively with the DHET/EET ratio, an indirect measurement of soluble epoxide hydrolase (sEH) activity, suggesting an important role of eicosanoids and sEH in HFrEF pathophysiology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NU23J-02-00015" target="_blank" >NU23J-02-00015: Nové farmakologické přístupy pro léčbu srdečního selhání s redukovanou ejekční frakcí kombinovaného s chronickým onemocněním ledvin.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

1336-0345

Svazek periodika

126

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

228-234

Kód UT WoS článku

001465540600011

EID výsledku v databázi Scopus

2-s2.0-85217772793