Frontiers in F-19-MR imaging : nanofluorides and F-19-CEST as novel extensions to the F-19-MRI toolbox

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083984" target="_blank" >RIV/00023001:_____/23:00083984 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlepdf/2023/cc/d3cc00562c" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2023/cc/d3cc00562c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d3cc00562c" target="_blank" >10.1039/d3cc00562c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Frontiers in F-19-MR imaging : nanofluorides and F-19-CEST as novel extensions to the F-19-MRI toolbox

Popis výsledku v původním jazyce

Fluorine-containing materials have enriched the field of molecular and cellular MRI with unambiguous and quantitative detection capabilities. The background-free &quot;hot-spot&quot; display and the large range of chemical shifts of the broad palette of F-19-formulations are now used for a variety of applications. The common features of these formulations are: (i) they are based on organic molecular backbones (i.e., organofluorines); and (ii) their F-19-MRI detectability relies on a well-defined and clearly observed F-19-MR signal. During the last few years, our lab aimed to expand the F-19-MR toolbox with new capabilities that were, thus far, not used in molecular and cellular F-19-MRI. This Feature Article summarizes our developments and implementations in the field of F-19-MRI emphasizing (i) the introduction of ultrasmall inorganic fluoride-based nanocrystals (nanofluorides) as nano-sized (&lt;10 nm) agents for F-19-MRI, and (ii) the use of Chemical Exchange Saturation Transfer (CEST) in the F-19-MRI framework to indirectly amplify F-19-MR signals of otherwise-undetected fluorinated entities.

Název v anglickém jazyce

Frontiers in F-19-MR imaging : nanofluorides and F-19-CEST as novel extensions to the F-19-MRI toolbox

Popis výsledku anglicky

Fluorine-containing materials have enriched the field of molecular and cellular MRI with unambiguous and quantitative detection capabilities. The background-free &quot;hot-spot&quot; display and the large range of chemical shifts of the broad palette of F-19-formulations are now used for a variety of applications. The common features of these formulations are: (i) they are based on organic molecular backbones (i.e., organofluorines); and (ii) their F-19-MRI detectability relies on a well-defined and clearly observed F-19-MR signal. During the last few years, our lab aimed to expand the F-19-MR toolbox with new capabilities that were, thus far, not used in molecular and cellular F-19-MRI. This Feature Article summarizes our developments and implementations in the field of F-19-MRI emphasizing (i) the introduction of ultrasmall inorganic fluoride-based nanocrystals (nanofluorides) as nano-sized (&lt;10 nm) agents for F-19-MRI, and (ii) the use of Chemical Exchange Saturation Transfer (CEST) in the F-19-MRI framework to indirectly amplify F-19-MR signals of otherwise-undetected fluorinated entities.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

<a href="/cs/project/GN22-13334I" target="_blank" >GN22-13334I: Geneticky modifikované extracelulární vezikuly jako nové zobrazovací a terapeutické látky pro specifické cílení do nádorové tkáně</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical communications

ISSN

1359-7345

e-ISSN

1364-548X

Svazek periodika

59

Číslo periodika v rámci svazku

37

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

5502-5513

Kód UT WoS článku

000973748400001

EID výsledku v databázi Scopus

2-s2.0-85153089841