Fluorine polymer probes for magnetic resonance imaging: quo vadis?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24530%2F19%3A00006470" target="_blank" >RIV/46747885:24530/19:00006470 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10334-018-0724-6" target="_blank" >http://dx.doi.org/10.1007/s10334-018-0724-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10334-018-0724-6" target="_blank" >10.1007/s10334-018-0724-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fluorine polymer probes for magnetic resonance imaging: quo vadis?

Popis výsledku v původním jazyce

Over the last few years, the development and relevance of 19 F magnetic resonance imaging (MRI) for use in clinical practice has emerged. MRI using fluorinated probes enables the achievement of a specific signal with high contrast in MRI images. However, to ensure sufficient sensitivity of 19 F MRI, fluorine probes with a high content of chemically equivalent fluorine atoms are required. The majority of 19 F MRI agents are perfluorocarbon emulsions, which have a broad range of applications in molecular imaging, although the content of fluorine atoms in these molecules is limited. In this review, we focus mainly on polymer probes that allow higher fluorine content and represent versatile platforms with properties tailorable to a plethora of biomedical in vivo applications. We discuss the chemical development, up to the first imaging applications, of these promising fluorine probes, including injectable polymers that form depots that are intended for possible use in cancer therapy.

Název v anglickém jazyce

Fluorine polymer probes for magnetic resonance imaging: quo vadis?

Popis výsledku anglicky

Over the last few years, the development and relevance of 19 F magnetic resonance imaging (MRI) for use in clinical practice has emerged. MRI using fluorinated probes enables the achievement of a specific signal with high contrast in MRI images. However, to ensure sufficient sensitivity of 19 F MRI, fluorine probes with a high content of chemically equivalent fluorine atoms are required. The majority of 19 F MRI agents are perfluorocarbon emulsions, which have a broad range of applications in molecular imaging, although the content of fluorine atoms in these molecules is limited. In this review, we focus mainly on polymer probes that allow higher fluorine content and represent versatile platforms with properties tailorable to a plethora of biomedical in vivo applications. We discuss the chemical development, up to the first imaging applications, of these promising fluorine probes, including injectable polymers that form depots that are intended for possible use in cancer therapy.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Magnetic Resonance Materials in Physics, Biology and Medicine

ISSN

1352-8661

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

173-185

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85057805912