Impact of circadian rhythm parameters on type 1 diabetes control

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084391" target="_blank" >RIV/00023001:_____/23:00084391 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Impact of circadian rhythm parameters on type 1 diabetes control

Popis výsledku v původním jazyce

Background and aims: Circadian rhythms, which run with a period closeto 24 h, are driven by an internal clock in the brain that responds to thelight/dark changes in our environment. This regulation results in dailyalternating states of alertness and sleepiness. An irregular circadian rhythmwith poor sleep habits has been proven to be a potential risk factor for type2 diabetes mellitus, whereas it is not fully explored how poor sleep hygieneafects type 1 diabetes mellitus (T1DM) control and its complications.Therefore, the aim of our study was to research whether sleep deprivationor misaligned sleep patterns correlate with key T1DM parameters.Materials and methods: A total of 383 patients with T1DM,mean age 46.8 years, mean diabetes duration 25.1 years completed The Munich ChronoType Questionnaire (MCTQ). TheMCTQ provides information on social jetlag - it refers to a discrepancy between sleep time on weekdays and weekends. Weexcluded shift workers or individuals who were travelling duringthe observation period. All patients were prospectively recruitedfrom the diabetes outpatient clinic, and all used effective glucosemonitoring via a subcutaneously implantable sensor device. Themean HbA1c was 53.7 mmol/mol and the mean time in range(TIR) was 69.4%. Data from the MCTQ questionnaire were usedto calculate social jetlag as the difference between the MSF (midsleep phase on free days) and the MSW (mid sleep phase on workdays). MSF on free days were normalized to age- and sex-corrected MSFsasc (“normalized chronotype,” a hypothetical chronotype at age 30). Subjects from the lowest and highest MSFsascdeciles were categorized as “Extremely early” and “Extremelylate” chronotypes (extremes), respectively, and the remainderwere categorized as “Non-extreme” chronotype, which includedslightly early, intermediate, and slightly late chronotypes. Spearman’s nonparametric correlation coefficients were calculated forassessing associations between continuous variables and T-testor ANOVA with Tukey’s post-hoc multiple comparison test forassessing associations between categorical variables and continuous variables.Results: Chronotype and social jetlag did not difer depending ongender. In addition, both chronotype and social jetlag showed no signifcant correlation with HbA1c and TIR (defned as glycaemia 3.9-10mmol/l). Shorter total sleep duration showed a slightly higher incidence of albuminuria (r=-0.19, p=0.019). Extremely early chronotypewas associated with worse mean TIR (compared by ANOVA andTukey test, p=0.029) and worse mean time above glycaemia 13.9mmol/l compared to normal chronotype (p=0.037).Conclusion: Our study showed that the sleep duration was associatedwith both T1DM control and albuminuria. Chronotype or social jetlagdid not signifcantly correlate with the control of T1DM. In the future,we aim to provide insight into further results from larger sample ofsubjects with worse glycaemic control.

Název v anglickém jazyce

Impact of circadian rhythm parameters on type 1 diabetes control

Popis výsledku anglicky

Background and aims: Circadian rhythms, which run with a period closeto 24 h, are driven by an internal clock in the brain that responds to thelight/dark changes in our environment. This regulation results in dailyalternating states of alertness and sleepiness. An irregular circadian rhythmwith poor sleep habits has been proven to be a potential risk factor for type2 diabetes mellitus, whereas it is not fully explored how poor sleep hygieneafects type 1 diabetes mellitus (T1DM) control and its complications.Therefore, the aim of our study was to research whether sleep deprivationor misaligned sleep patterns correlate with key T1DM parameters.Materials and methods: A total of 383 patients with T1DM,mean age 46.8 years, mean diabetes duration 25.1 years completed The Munich ChronoType Questionnaire (MCTQ). TheMCTQ provides information on social jetlag - it refers to a discrepancy between sleep time on weekdays and weekends. Weexcluded shift workers or individuals who were travelling duringthe observation period. All patients were prospectively recruitedfrom the diabetes outpatient clinic, and all used effective glucosemonitoring via a subcutaneously implantable sensor device. Themean HbA1c was 53.7 mmol/mol and the mean time in range(TIR) was 69.4%. Data from the MCTQ questionnaire were usedto calculate social jetlag as the difference between the MSF (midsleep phase on free days) and the MSW (mid sleep phase on workdays). MSF on free days were normalized to age- and sex-corrected MSFsasc (“normalized chronotype,” a hypothetical chronotype at age 30). Subjects from the lowest and highest MSFsascdeciles were categorized as “Extremely early” and “Extremelylate” chronotypes (extremes), respectively, and the remainderwere categorized as “Non-extreme” chronotype, which includedslightly early, intermediate, and slightly late chronotypes. Spearman’s nonparametric correlation coefficients were calculated forassessing associations between continuous variables and T-testor ANOVA with Tukey’s post-hoc multiple comparison test forassessing associations between categorical variables and continuous variables.Results: Chronotype and social jetlag did not difer depending ongender. In addition, both chronotype and social jetlag showed no signifcant correlation with HbA1c and TIR (defned as glycaemia 3.9-10mmol/l). Shorter total sleep duration showed a slightly higher incidence of albuminuria (r=-0.19, p=0.019). Extremely early chronotypewas associated with worse mean TIR (compared by ANOVA andTukey test, p=0.029) and worse mean time above glycaemia 13.9mmol/l compared to normal chronotype (p=0.037).Conclusion: Our study showed that the sleep duration was associatedwith both T1DM control and albuminuria. Chronotype or social jetlagdid not signifcantly correlate with the control of T1DM. In the future,we aim to provide insight into further results from larger sample ofsubjects with worse glycaemic control.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů