Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00573072" target="_blank" >RIV/67985823:_____/23:00573072 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378025:_____/23:00573072

Výsledek na webu

<a href="https://doi.org/10.1093/sleep/zsad037" target="_blank" >https://doi.org/10.1093/sleep/zsad037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/sleep/zsad037" target="_blank" >10.1093/sleep/zsad037</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules

Popis výsledku v původním jazyce

Study ObjectivesSocial jetlag manifests as a difference in sleep timing on workdays and free days. Social jetlag is often associated with shorter, lower-quality sleep, so it is unclear how much the chronic circadian misalignment contributes to observed negative health outcomes. We aimed to (1) investigate associations between social jetlag, chronotype (one of its determinants), and the levels of health markers, (2) describe factors associated with social jetlag, and (3) examine whether working from home can reduce social jetlag.MethodsAdult respondents participated in a nationally representative longitudinal survey of Czech households (individuals in each wave: n(2018/19/20) = 5132/1957/1533), which included Munich ChronoType Questionnaire to evaluate chronotype and social jetlag. A subset provided blood samples (n(2019) = 1957) for detection of nine biomarkers and was surveyed in three successive years (social jetlag calculated for n(2018/19/20) = 3930/1601/1237). Data were analyzed by nonparametric univariate tests and mixed effects multivariate regression with social jetlag, chronotype, sex, age, body-mass index, and reported diseases as predictors and biomarker levels as outcomes.ResultsHigher social jetlag (>= 0.65 h) was significantly associated with increased levels of total cholesterol and low-density lipoprotein cholesterol, particularly in participants older than 50 years (Mann-Whitney, men: p(CHL) = 0.0005, p(LDL) = 0.0009, women: p(CHL) = 0.0079, p(LDL) = 0.0068). Extreme chronotypes were associated with cardiovascular disease risk markers regardless of social jetlag (Kruskal-Wallis, p < 0.0001). Commuting to work and time stress were identified as important contributors to social jetlag. Individual longitudinal data showed that working from home decreased social jetlag and prolonged sleep.ConclusionsWe report significant associations between sleep phase preference, social jetlag, and cardio-metabolic biomarkers.

Název v anglickém jazyce

Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules

Popis výsledku anglicky

Study ObjectivesSocial jetlag manifests as a difference in sleep timing on workdays and free days. Social jetlag is often associated with shorter, lower-quality sleep, so it is unclear how much the chronic circadian misalignment contributes to observed negative health outcomes. We aimed to (1) investigate associations between social jetlag, chronotype (one of its determinants), and the levels of health markers, (2) describe factors associated with social jetlag, and (3) examine whether working from home can reduce social jetlag.MethodsAdult respondents participated in a nationally representative longitudinal survey of Czech households (individuals in each wave: n(2018/19/20) = 5132/1957/1533), which included Munich ChronoType Questionnaire to evaluate chronotype and social jetlag. A subset provided blood samples (n(2019) = 1957) for detection of nine biomarkers and was surveyed in three successive years (social jetlag calculated for n(2018/19/20) = 3930/1601/1237). Data were analyzed by nonparametric univariate tests and mixed effects multivariate regression with social jetlag, chronotype, sex, age, body-mass index, and reported diseases as predictors and biomarker levels as outcomes.ResultsHigher social jetlag (>= 0.65 h) was significantly associated with increased levels of total cholesterol and low-density lipoprotein cholesterol, particularly in participants older than 50 years (Mann-Whitney, men: p(CHL) = 0.0005, p(LDL) = 0.0009, women: p(CHL) = 0.0079, p(LDL) = 0.0068). Extreme chronotypes were associated with cardiovascular disease risk markers regardless of social jetlag (Kruskal-Wallis, p < 0.0001). Commuting to work and time stress were identified as important contributors to social jetlag. Individual longitudinal data showed that working from home decreased social jetlag and prolonged sleep.ConclusionsWe report significant associations between sleep phase preference, social jetlag, and cardio-metabolic biomarkers.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sleep

ISSN

0161-8105

e-ISSN

1550-9109

Svazek periodika

46

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

zsad037

Kód UT WoS článku

000973377000001

EID výsledku v databázi Scopus

2-s2.0-85162244955