Self-assembled fluorinated nanoparticles as sensitive and biocompatible theranostic platforms for 19F MRI

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084916" target="_blank" >RIV/00023001:_____/24:00084916 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/24:10477853 RIV/46747885:24530/24:00013002 RIV/00216208:11110/24:10477853

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202300510" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202300510</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mabi.202300510" target="_blank" >10.1002/mabi.202300510</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Self-assembled fluorinated nanoparticles as sensitive and biocompatible theranostic platforms for 19F MRI

Popis výsledku v původním jazyce

Theranostics is a novel paradigm integrating therapy and diagnostics, thereby providing new prospects for overcoming the limitations of traditional treatments. In this context, perfluorocarbons (PFCs) are the most widely used tracers in preclinical fluorine-19 magnetic resonance (F-19 MR), primarily for their high fluorine content. However, PFCs are extremely hydrophobic, and their solutions often display reduced biocompatibility, relative instability, and subpar F-19 MR relaxation times. This study aims to explore the potential of micellar F-19 MR imaging (MRI) tracers, synthesized by polymerization-induced self-assembly (PISA), as alternative theranostic agents for simultaneous imaging and release of the non-steroidal antileprotic drug clofazimine. In vitro, under physiological conditions, these micelles demonstrate sustained drug release. In vivo, throughout the drug release process, they provide a highly specific and sensitive F-19 MRI signal. Even after extended exposure, these fluoropolymer tracers show biocompatibility, as confirmed by the histological analysis. Moreover, the characteristics of these polymers can be broadly adjusted by design to meet the wide range of criteria for preclinical and clinical settings. Therefore, micellar 19F MRI tracers display physicochemical properties suitable for in vivo imaging, such as relaxation times and non-toxicity, and high performance as drug carriers, highlighting their potential as both diagnostic and therapeutic tools.

Název v anglickém jazyce

Self-assembled fluorinated nanoparticles as sensitive and biocompatible theranostic platforms for 19F MRI

Popis výsledku anglicky

Theranostics is a novel paradigm integrating therapy and diagnostics, thereby providing new prospects for overcoming the limitations of traditional treatments. In this context, perfluorocarbons (PFCs) are the most widely used tracers in preclinical fluorine-19 magnetic resonance (F-19 MR), primarily for their high fluorine content. However, PFCs are extremely hydrophobic, and their solutions often display reduced biocompatibility, relative instability, and subpar F-19 MR relaxation times. This study aims to explore the potential of micellar F-19 MR imaging (MRI) tracers, synthesized by polymerization-induced self-assembly (PISA), as alternative theranostic agents for simultaneous imaging and release of the non-steroidal antileprotic drug clofazimine. In vitro, under physiological conditions, these micelles demonstrate sustained drug release. In vivo, throughout the drug release process, they provide a highly specific and sensitive F-19 MRI signal. Even after extended exposure, these fluoropolymer tracers show biocompatibility, as confirmed by the histological analysis. Moreover, the characteristics of these polymers can be broadly adjusted by design to meet the wide range of criteria for preclinical and clinical settings. Therefore, micellar 19F MRI tracers display physicochemical properties suitable for in vivo imaging, such as relaxation times and non-toxicity, and high performance as drug carriers, highlighting their potential as both diagnostic and therapeutic tools.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecular bioscience

ISSN

1616-5187

e-ISSN

1616-5195

Svazek periodika

24

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

"art. no. 2300510"

Kód UT WoS článku

001144788700001

EID výsledku v databázi Scopus

2-s2.0-85182454477