Selected Genetic Characteristics of the Vietnamese Minority Living in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085789" target="_blank" >RIV/00023001:_____/25:00085789 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10498446 RIV/00064165:_____/25:10498446

Výsledek na webu

<a href="https://foliabiologica.lf1.cuni.cz/71/1/0001/#acknowledgements" target="_blank" >https://foliabiologica.lf1.cuni.cz/71/1/0001/#acknowledgements</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/fb2025071010001" target="_blank" >10.14712/fb2025071010001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Selected Genetic Characteristics of the Vietnamese Minority Living in the Czech Republic

Popis výsledku v původním jazyce

The aim of this study was to analyse the allelic distribution of selected genes in the Czech and Vietnamese populations. We analysed samples from 94 Vietnamese volunteers and 2,859 Czech population-based subjects (2,559 from the Czechs post-MONICA and 300 volunteers from the South region of the Czech Republic). There were significant differences between the two populations for most, but not all, of the SNPs analysed. In particular, the prevalence of risk alleles in the analysed polymorphisms tended to be lower in the Vietnamese community compared to the Czech population, especially within the FTO (rs17817449; associated with obesity risk, P &lt; 0.0001), TCF7L2 (rs7903146; linked to type 2 diabetes, P &lt; 0.0001) and ADH1B (rs1229984; related to alcohol consumption, P &lt; 0.0001) genes. The genotype within the MCM6/LCT cluster (rs4988235) associated with lactase persistence was not present in the Vietnamese population. Slight genotype differences were detected for one HFE polymorphism (rs1799945 with P = 0.005; but not for rs1800562). Only the genotype frequencies within the MC4R and APOE genes were almost identical in both populations. We conclude that the Vietnamese population may have a lower genetic predisposition to the non-communicable diseases such as obesity or diabetes mellitus.

Název v anglickém jazyce

Selected Genetic Characteristics of the Vietnamese Minority Living in the Czech Republic

Popis výsledku anglicky

The aim of this study was to analyse the allelic distribution of selected genes in the Czech and Vietnamese populations. We analysed samples from 94 Vietnamese volunteers and 2,859 Czech population-based subjects (2,559 from the Czechs post-MONICA and 300 volunteers from the South region of the Czech Republic). There were significant differences between the two populations for most, but not all, of the SNPs analysed. In particular, the prevalence of risk alleles in the analysed polymorphisms tended to be lower in the Vietnamese community compared to the Czech population, especially within the FTO (rs17817449; associated with obesity risk, P &lt; 0.0001), TCF7L2 (rs7903146; linked to type 2 diabetes, P &lt; 0.0001) and ADH1B (rs1229984; related to alcohol consumption, P &lt; 0.0001) genes. The genotype within the MCM6/LCT cluster (rs4988235) associated with lactase persistence was not present in the Vietnamese population. Slight genotype differences were detected for one HFE polymorphism (rs1799945 with P = 0.005; but not for rs1800562). Only the genotype frequencies within the MC4R and APOE genes were almost identical in both populations. We conclude that the Vietnamese population may have a lower genetic predisposition to the non-communicable diseases such as obesity or diabetes mellitus.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia biologica (Praha)

ISSN

0015-5500

e-ISSN

2533-7602

Svazek periodika

71

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

001481847100001

EID výsledku v databázi Scopus

2-s2.0-105004481391