Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F20%3A43902458" target="_blank" >RIV/60076658:12110/20:43902458 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/20:00080248

Výsledek na webu

<a href="https://doi.org/10.1002/mgg3.1361" target="_blank" >https://doi.org/10.1002/mgg3.1361</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mgg3.1361" target="_blank" >10.1002/mgg3.1361</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population

Popis výsledku v původním jazyce

The Czech governmental study suggests up to a 25% higher prevalence of type 2 diabetes mellitus (T2DM) in the Roma population than within the majority population. It is not known whether and to what extent these differences have a genetic background. Methods To analyze whether the frequencies of the alleles/genotypes of the FTO, TCF7L2, CDKN2A/2B, MAEA, TLE4, IGF2BP2, ARAP1, and KCNJ11 genes differ between the two major ethnic groups in the Czech Republic, we examined them in DNA samples from 302 Roma individuals and 298 Czech individuals. Results Compared to the majority population, Roma are more likely to carry risk alleles in the FTO (26% vs. 16% GG homozygotes, p &lt; .01), IGF2BP2 (22% vs. 10% TT homozygotes, p &lt; .0001), ARAP1 (98% vs. 95% of A allele carriers, p &lt; .005), and CDKN2A/2B (81% vs. 66% of TT homozygotes, p &lt; .001) genes; however, less frequently they are carriers of the TCF7L2 risk allele (34% vs. 48% of the T allele p &lt; .0005). Finally, we found significant accumulation of T2DM‐associated alleles between the Roma population in comparison with the majority population (25.4% vs. 15.2% of the carriers of at least 12 risk alleles; p &lt; .0001). Conclusion The increased prevalence of T2DM in the Roma population may have a background in different frequencies of the risk alleles of genes associated with T2DM development.

Název v anglickém jazyce

Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population

Popis výsledku anglicky

The Czech governmental study suggests up to a 25% higher prevalence of type 2 diabetes mellitus (T2DM) in the Roma population than within the majority population. It is not known whether and to what extent these differences have a genetic background. Methods To analyze whether the frequencies of the alleles/genotypes of the FTO, TCF7L2, CDKN2A/2B, MAEA, TLE4, IGF2BP2, ARAP1, and KCNJ11 genes differ between the two major ethnic groups in the Czech Republic, we examined them in DNA samples from 302 Roma individuals and 298 Czech individuals. Results Compared to the majority population, Roma are more likely to carry risk alleles in the FTO (26% vs. 16% GG homozygotes, p &lt; .01), IGF2BP2 (22% vs. 10% TT homozygotes, p &lt; .0001), ARAP1 (98% vs. 95% of A allele carriers, p &lt; .005), and CDKN2A/2B (81% vs. 66% of TT homozygotes, p &lt; .001) genes; however, less frequently they are carriers of the TCF7L2 risk allele (34% vs. 48% of the T allele p &lt; .0005). Finally, we found significant accumulation of T2DM‐associated alleles between the Roma population in comparison with the majority population (25.4% vs. 15.2% of the carriers of at least 12 risk alleles; p &lt; .0001). Conclusion The increased prevalence of T2DM in the Roma population may have a background in different frequencies of the risk alleles of genes associated with T2DM development.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Genetics and Genomic Medicine

ISSN

2324-9269

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

"e1361"

Kód UT WoS článku

000542409400001

EID výsledku v databázi Scopus

2-s2.0-85087287430