Safety and efficacy of a temperature-controlled ablation system for ventricular tachycardia: Results from the TRAC-VT study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085793" target="_blank" >RIV/00023001:_____/25:00085793 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s10840-025-01995-z" target="_blank" >https://link.springer.com/article/10.1007/s10840-025-01995-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10840-025-01995-z" target="_blank" >10.1007/s10840-025-01995-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Safety and efficacy of a temperature-controlled ablation system for ventricular tachycardia: Results from the TRAC-VT study

Popis výsledku v původním jazyce

BackgroundCatheter ablation using radiofrequency (RF) energy is an established treatment for ventricular tachycardia (VT). Tissue temperature is a key determinant of successful lesion creation, and yet, it is difficult to measure during conventional RF ablation because of the cooling effect of high-flow rate saline irrigation. The TRAC-VT study evaluated the safety and efficacy of a novel irrigated RF ablation system modulating power based on real-time tissue temperature.MethodsPatients with sustained monomorphic VT and structural heart disease (SHD) were enrolled. Catheter ablation was performed in temperature-control mode (irrigation 8 ml/min, temperature set-points 55 or 60 degrees C, and power output &lt;= 50 W), with RF applications for &lt;= 45 s. The primary safety endpoint was a composite of cardiovascular-specific serious procedure-related adverse events within 30 days post-ablation. The primary effectiveness endpoint was acute success (i.e., non-inducibility of all clinically relevant VTs).ResultsThirty-eight patients were enrolled with monomorphic VT (age 68 +/- 12 years and 84% male), with an average of 1.7 +/- 1.2 VTs targeted per patient. In total, 41 +/- 23 RF applications per patient were delivered. Acute procedural success was 100% (95% CI, 91-100%). No primary safety endpoints were observed. Six-month follow-up was completed in 92% of patients with 81% (95% CI, 65-91%) freedom from sustained or treated VT. A repeat ablation was performed in three patients.ConclusionsAblation of VT in SHD, using a temperature-controlled irrigated RF catheter, was safe and effective with a low rate of VT recurrence at 6 months.

Název v anglickém jazyce

Safety and efficacy of a temperature-controlled ablation system for ventricular tachycardia: Results from the TRAC-VT study

Popis výsledku anglicky

BackgroundCatheter ablation using radiofrequency (RF) energy is an established treatment for ventricular tachycardia (VT). Tissue temperature is a key determinant of successful lesion creation, and yet, it is difficult to measure during conventional RF ablation because of the cooling effect of high-flow rate saline irrigation. The TRAC-VT study evaluated the safety and efficacy of a novel irrigated RF ablation system modulating power based on real-time tissue temperature.MethodsPatients with sustained monomorphic VT and structural heart disease (SHD) were enrolled. Catheter ablation was performed in temperature-control mode (irrigation 8 ml/min, temperature set-points 55 or 60 degrees C, and power output &lt;= 50 W), with RF applications for &lt;= 45 s. The primary safety endpoint was a composite of cardiovascular-specific serious procedure-related adverse events within 30 days post-ablation. The primary effectiveness endpoint was acute success (i.e., non-inducibility of all clinically relevant VTs).ResultsThirty-eight patients were enrolled with monomorphic VT (age 68 +/- 12 years and 84% male), with an average of 1.7 +/- 1.2 VTs targeted per patient. In total, 41 +/- 23 RF applications per patient were delivered. Acute procedural success was 100% (95% CI, 91-100%). No primary safety endpoints were observed. Six-month follow-up was completed in 92% of patients with 81% (95% CI, 65-91%) freedom from sustained or treated VT. A repeat ablation was performed in three patients.ConclusionsAblation of VT in SHD, using a temperature-controlled irrigated RF catheter, was safe and effective with a low rate of VT recurrence at 6 months.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of interventional cardiac electrophysiology: an international journal of arrhythmias and pacing

ISSN

1383-875X

e-ISSN

1572-8595

Svazek periodika

68

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

"1217–1224"

Kód UT WoS článku

001410565500001

EID výsledku v databázi Scopus

2-s2.0-85217397542