Gut Hormone Levels During Mixed Liquid Meal Test in Short Bowel Syndrome, the Possible Influence on the Intestine Adaptation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085842" target="_blank" >RIV/00023001:_____/25:00085842 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10501590 RIV/00064165:_____/25:10501590

Výsledek na webu

<a href="https://www.biomed.cas.cz/physiolres/pdf/2025/74_645.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2025/74_645.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.935559" target="_blank" >10.33549/physiolres.935559</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gut Hormone Levels During Mixed Liquid Meal Test in Short Bowel Syndrome, the Possible Influence on the Intestine Adaptation

Popis výsledku v původním jazyce

Short bowel syndrome (SBS) is an intestinal disorder characterized by reduced length of the gut most due to intestinal resection, resulting in malabsorption, malnutrition, and water and electrolyte disturbances. Intestinal adaptation is a long-term process in which GIT hormones, growth peptides, cytokines etc. are involved. These mechanisms have not been fully clarified yet. The most important seem to be GLP-2 and other gut hormones. The aim of our study was to consider the changes of the levels of selected gut hormones and parameters of glucose homeostasis during the mixed liquid meal test in one year of follow up after the gut resection. Seventeen patients with SBS type I were included into our study. The meal test and measuring of selected parameters (GLP-2, GLP-1, ghrelin, insulin, glucagon, GIP, amylin) were conducted after 2 weeks, 6 and 12 months from its initiation, respectively. During one year of this study patients&lt;acute accent&gt; nutritional status improved due to sufficient parenteral nutrition, despite no change in body weight. Hormones possibly involved in intestinal adaptation (GLP-2, GLP-1, ghrelin) did not differ in meal test, neither levels nor AUC. Only higher insulin and glucose levels after one year of follow-up may indicate the beginning of intestinal adaptation process and improving intestinal functions. We conclude that impaired GLP-2 secretion is probably the main reason for the limited adaptation ability in patients with SBS type I.

Název v anglickém jazyce

Gut Hormone Levels During Mixed Liquid Meal Test in Short Bowel Syndrome, the Possible Influence on the Intestine Adaptation

Popis výsledku anglicky

Short bowel syndrome (SBS) is an intestinal disorder characterized by reduced length of the gut most due to intestinal resection, resulting in malabsorption, malnutrition, and water and electrolyte disturbances. Intestinal adaptation is a long-term process in which GIT hormones, growth peptides, cytokines etc. are involved. These mechanisms have not been fully clarified yet. The most important seem to be GLP-2 and other gut hormones. The aim of our study was to consider the changes of the levels of selected gut hormones and parameters of glucose homeostasis during the mixed liquid meal test in one year of follow up after the gut resection. Seventeen patients with SBS type I were included into our study. The meal test and measuring of selected parameters (GLP-2, GLP-1, ghrelin, insulin, glucagon, GIP, amylin) were conducted after 2 weeks, 6 and 12 months from its initiation, respectively. During one year of this study patients&lt;acute accent&gt; nutritional status improved due to sufficient parenteral nutrition, despite no change in body weight. Hormones possibly involved in intestinal adaptation (GLP-2, GLP-1, ghrelin) did not differ in meal test, neither levels nor AUC. Only higher insulin and glucose levels after one year of follow-up may indicate the beginning of intestinal adaptation process and improving intestinal functions. We conclude that impaired GLP-2 secretion is probably the main reason for the limited adaptation ability in patients with SBS type I.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological research

ISSN

0862-8408

e-ISSN

1802-9973

Svazek periodika

74

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

645-655

Kód UT WoS článku

001568778000011

EID výsledku v databázi Scopus

2-s2.0-105015013119