Ten millennia of hepatitis B virus evolution
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023272%3A_____%2F21%3A10135236" target="_blank" >RIV/00023272:_____/21:10135236 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.science.org/doi/abs/10.1126/science.abi5658" target="_blank" >https://www.science.org/doi/abs/10.1126/science.abi5658</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.abi5658" target="_blank" >10.1126/science.abi5658</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Ten millennia of hepatitis B virus evolution
Popis výsledku v původním jazyce
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.
Název v anglickém jazyce
Ten millennia of hepatitis B virus evolution
Popis výsledku anglicky
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10607 - Virology
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Science
ISSN
1095-9203
e-ISSN
—
Svazek periodika
374
Číslo periodika v rámci svazku
6564
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
182-188
Kód UT WoS článku
000704920400041
EID výsledku v databázi Scopus
2-s2.0-85118031627