Earliest modern human genomes constrain timing of Neandertal admixture

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023272%3A_____%2F24%3A10136717" target="_blank" >RIV/00023272:_____/24:10136717 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41586-024-08420-x" target="_blank" >https://www.nature.com/articles/s41586-024-08420-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41586-024-08420-x" target="_blank" >10.1038/s41586-024-08420-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Earliest modern human genomes constrain timing of Neandertal admixture

Popis výsledku v původním jazyce

Modern humans arrived in Europe more than 45,000 years ago, overlapping at least 5,000 years with Neanderthals1-4. Limited genomic data from these early modern humans have shown that at least two genetically distinct groups inhabited Europe, represented by Zlaty kun, Czechia3 and Bacho Kiro, Bulgaria2. Here we deepen our understanding of early modern humans by analyzing one high-coverage genome and five low-coverage genomes from ~45,000 year-old remains from Ilsenhohle in Ranis, Germany4, and a further high-coverage genome from Zlaty kun. We show that distant familial relationships link the Ranis and Zlaty kun individuals and that they were part of the same small, isolated population that represents the deepest known split from the Out-of-Africa lineage. Ranis genomes harbor Neanderthal segments that originate from a single admixture event shared with all non-Africans that we date to ~45,000-49,000 years ago. This implies that ancestors of all non-Africans sequenced to-date resided in a common population at this time, and further suggests that modern human remains older than 50,000 years from outside Africa represent different non-African populations.

Název v anglickém jazyce

Earliest modern human genomes constrain timing of Neandertal admixture

Popis výsledku anglicky

Modern humans arrived in Europe more than 45,000 years ago, overlapping at least 5,000 years with Neanderthals1-4. Limited genomic data from these early modern humans have shown that at least two genetically distinct groups inhabited Europe, represented by Zlaty kun, Czechia3 and Bacho Kiro, Bulgaria2. Here we deepen our understanding of early modern humans by analyzing one high-coverage genome and five low-coverage genomes from ~45,000 year-old remains from Ilsenhohle in Ranis, Germany4, and a further high-coverage genome from Zlaty kun. We show that distant familial relationships link the Ranis and Zlaty kun individuals and that they were part of the same small, isolated population that represents the deepest known split from the Out-of-Africa lineage. Ranis genomes harbor Neanderthal segments that originate from a single admixture event shared with all non-Africans that we date to ~45,000-49,000 years ago. This implies that ancestors of all non-Africans sequenced to-date resided in a common population at this time, and further suggests that modern human remains older than 50,000 years from outside Africa represent different non-African populations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10620 - Other biological topics

Projekt

<a href="/cs/project/GA23-06822S" target="_blank" >GA23-06822S: Lidské kosterní pozůstatky ze Zlatého koně: revize a nové interpretace výzkumu z 20. století v Koněpruských jeskyních</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature

ISSN

1476-4687

e-ISSN

—

Svazek periodika

638

Číslo periodika v rámci svazku

8051

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

711-717

Kód UT WoS článku

001408584500001

EID výsledku v databázi Scopus

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