Postpartum epigenetic profile of cardiovascular microRNAs in women exposed to pregnancy-related complications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F20%3AN0000006" target="_blank" >RIV/00023698:_____/20:N0000006 - isvavai.cz</a>

Výsledek na webu

<a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020088704&tab=PCTBIBLIO&_cid=P10-KA2B6F-45104-1" target="_blank" >https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020088704&tab=PCTBIBLIO&_cid=P10-KA2B6F-45104-1</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Postpartum epigenetic profile of cardiovascular microRNAs in women exposed to pregnancy-related complications

Popis výsledku v původním jazyce

The present invention provides a method of predicting a risk of onset and development of cardiovascular and/or cerebrovascular disease for a woman with a history of pregnancy-related complications selected from gestational hypertension, preeclampsia and/or fetal growth restriction, said method comprising the steps of: - determining the level of expression of at least one microRNA marker selected from the group consisting of miR-1-3p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-29a-3p, miR-100-5p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-199a-5p, miR-221-3p, and miR-499a-5p and combinations thereof, in a whole peripheral venous blood sample taken from the woman postpartum at least 3 years after delivery, preferably 3-11 years after delivery; - comparing the determined level(s) of expression of the said at least one microRNA marker with a reference cut-off value, wherein said reference cut-off value is obtained by statistical analysis of samples from women with a history of pregnancy-related complications and samples from women without a history of pregnancy-related complications; - wherein the upregulation of the said at least one microRNA marker exceeding the reference cut-off value indicates the risk of onset and development of cardiovascular and/or cerebrovascular disease for the woman.

Název v anglickém jazyce

Postpartum epigenetic profile of cardiovascular microRNAs in women exposed to pregnancy-related complications

Popis výsledku anglicky

The present invention provides a method of predicting a risk of onset and development of cardiovascular and/or cerebrovascular disease for a woman with a history of pregnancy-related complications selected from gestational hypertension, preeclampsia and/or fetal growth restriction, said method comprising the steps of: - determining the level of expression of at least one microRNA marker selected from the group consisting of miR-1-3p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-29a-3p, miR-100-5p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-199a-5p, miR-221-3p, and miR-499a-5p and combinations thereof, in a whole peripheral venous blood sample taken from the woman postpartum at least 3 years after delivery, preferably 3-11 years after delivery; - comparing the determined level(s) of expression of the said at least one microRNA marker with a reference cut-off value, wherein said reference cut-off value is obtained by statistical analysis of samples from women with a history of pregnancy-related complications and samples from women without a history of pregnancy-related complications; - wherein the upregulation of the said at least one microRNA marker exceeding the reference cut-off value indicates the risk of onset and development of cardiovascular and/or cerebrovascular disease for the woman.

Druh

P - Patent

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Číslo patentu nebo vzoru

NV16-27761A

Vydavatel

EPO_1 -

Název vydavatele

European Patent Office

Místo vydání

Munich, The Hague, Berlin, Vienna, Brussels

Stát vydání

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Datum přijetí

7. 5. 2020

Název vlastníka

Univerzita Karlova, 3. lékařská fakulta

Způsob využití

A - Výsledek využívá pouze poskytovatel

Druh možnosti využití

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence