A method of predicting a risk of cardiovascular disease for a child born from a complicated pregnancy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43919394" target="_blank" >RIV/00216208:11120/20:43919394 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023698:_____/20:N0000007

Výsledek na webu

<a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020088703&_cid=P10-KA2BWZ-56206-1" target="_blank" >https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020088703&_cid=P10-KA2BWZ-56206-1</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A method of predicting a risk of cardiovascular disease for a child born from a complicated pregnancy

Popis výsledku v původním jazyce

The present invention provides a method of predicting a risk of onset and development of cardiovascular disease for a child born from a pregnancy complicated by gestational hypertension, preeclampsia and/or fetal growth restriction, or in a child born from a physiological pregnancy having an abnormal postnatal clinical finding, said method comprising the steps of: - determining the level of expression of at least one microRNA marker selected from the group consisting of miR-1-3p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-26a-5p, miR-29a-3p, miR-103a-3p, miR-125b-5p, miR-126-3p, miR-133a-3p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-210-3p, miR-342-3p and combinations thereof, in a sample of blood taken from the child; - comparing the determined level(s) of expression of the said at least one microRNA marker with reference cut-off value, wherein said reference cut-off value is obtained by statistical analysis of samples from children from physiological pregnancies and samples from children from complicated pregnancies; - wherein the aberrant regulation of the said at least one microRNA marker exceeding the reference cut-off value, or below the reference cut-off value, respectively, indicates the risk of onset and development of cardiovascular disease for the child.

Název v anglickém jazyce

A method of predicting a risk of cardiovascular disease for a child born from a complicated pregnancy

Popis výsledku anglicky

The present invention provides a method of predicting a risk of onset and development of cardiovascular disease for a child born from a pregnancy complicated by gestational hypertension, preeclampsia and/or fetal growth restriction, or in a child born from a physiological pregnancy having an abnormal postnatal clinical finding, said method comprising the steps of: - determining the level of expression of at least one microRNA marker selected from the group consisting of miR-1-3p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-26a-5p, miR-29a-3p, miR-103a-3p, miR-125b-5p, miR-126-3p, miR-133a-3p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-210-3p, miR-342-3p and combinations thereof, in a sample of blood taken from the child; - comparing the determined level(s) of expression of the said at least one microRNA marker with reference cut-off value, wherein said reference cut-off value is obtained by statistical analysis of samples from children from physiological pregnancies and samples from children from complicated pregnancies; - wherein the aberrant regulation of the said at least one microRNA marker exceeding the reference cut-off value, or below the reference cut-off value, respectively, indicates the risk of onset and development of cardiovascular disease for the child.

Druh

P - Patent

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/NV16-27761A" target="_blank" >NV16-27761A: Dlouhodobé sledování komplexního kardiovaskulárního profilu matky, plodu a dětí narozených z patologické gravidity</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Číslo patentu nebo vzoru

WO/2020/088703

Vydavatel

EPO_1 -

Název vydavatele

European Patent Office

Místo vydání

Munich, The Hague, Berlin, Vienna, Brussels

Stát vydání

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Datum přijetí

7. 5. 2020

Název vlastníka

Univerzita Karlova, 3. lékařská fakulta

Způsob využití

A - Výsledek využívá pouze poskytovatel

Druh možnosti využití

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence