Vaginal changes after ovariectomy in ewes: A large animal model for genitourinary syndrome of menopause

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F23%3AN0000019" target="_blank" >RIV/00023698:_____/23:N0000019 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/23:43925428

Výsledek na webu

<a href="https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14816" target="_blank" >https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14816</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ijgo.14816" target="_blank" >10.1002/ijgo.14816</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vaginal changes after ovariectomy in ewes: A large animal model for genitourinary syndrome of menopause

Popis výsledku v původním jazyce

ObjectiveTo evaluate the effect of iatrogenic menopause on the physiology of the vagina of the ewe and to evaluate if vaginal changes in ewes can be translated to women with genitourinary syndrome of menopause (GSM). MethodsPreclinical research with Dohne Merino ewes. Iatrogenic menopause was induced by bilateral ovariectomy (OVX). Animals were randomized for surgery, blinded for allocation and outcome assessment. Differences between groups were determined by linear regression analyses at 5 months after OVX. Outcome measures were vaginal epithelial thickness, pH, vaginal maturation value, vaginal maturation index, epithelial glycogen accumulation, content of elastin fibers, collagen, and vascularity. ResultsOVX ewes (n = 20) showed epithelial thinning of the vaginal wall from 146 mu m to 47 mu m (mean, P < 0.001). Furthermore, epithelial glycogen accumulation and vascularity of the vaginal wall significantly decreased (43% and 23%, respectively) as compared with the control group (no intervention; n = 5). No significant differences were found for other outcome measures. ConclusionThis study established the ewe as a suitable large animal model for GSM. Furthermore, the similar relevant outcomes in humans and ewes hold great value for future translational research for the evaluation and optimization of different treatment modalities for GSM.

Název v anglickém jazyce

Vaginal changes after ovariectomy in ewes: A large animal model for genitourinary syndrome of menopause

Popis výsledku anglicky

ObjectiveTo evaluate the effect of iatrogenic menopause on the physiology of the vagina of the ewe and to evaluate if vaginal changes in ewes can be translated to women with genitourinary syndrome of menopause (GSM). MethodsPreclinical research with Dohne Merino ewes. Iatrogenic menopause was induced by bilateral ovariectomy (OVX). Animals were randomized for surgery, blinded for allocation and outcome assessment. Differences between groups were determined by linear regression analyses at 5 months after OVX. Outcome measures were vaginal epithelial thickness, pH, vaginal maturation value, vaginal maturation index, epithelial glycogen accumulation, content of elastin fibers, collagen, and vascularity. ResultsOVX ewes (n = 20) showed epithelial thinning of the vaginal wall from 146 mu m to 47 mu m (mean, P < 0.001). Furthermore, epithelial glycogen accumulation and vascularity of the vaginal wall significantly decreased (43% and 23%, respectively) as compared with the control group (no intervention; n = 5). No significant differences were found for other outcome measures. ConclusionThis study established the ewe as a suitable large animal model for GSM. Furthermore, the similar relevant outcomes in humans and ewes hold great value for future translational research for the evaluation and optimization of different treatment modalities for GSM.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30213 - Transplantation

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

ISSN

0020-7292

e-ISSN

1879-3479

Svazek periodika

162

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1042-1049

Kód UT WoS článku

000982376800001

EID výsledku v databázi Scopus

2-s2.0-85158123196