Vaginal Er:YAG laser application in the menopausal ewe model: a randomised estrogen and sham-controlled trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43920617" target="_blank" >RIV/00216208:11120/21:43920617 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023698:_____/21:N0000023

Výsledek na webu

<a href="https://doi.org/10.1111/1471-0528.16558" target="_blank" >https://doi.org/10.1111/1471-0528.16558</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1471-0528.16558" target="_blank" >10.1111/1471-0528.16558</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vaginal Er:YAG laser application in the menopausal ewe model: a randomised estrogen and sham-controlled trial

Popis výsledku v původním jazyce

OBJECTIVE: To describe effects of non-ablative Er:YAG LASER on vaginal atrophy induced by iatrogenic menopause in the ewe. DESIGN: Animal experimental, randomised, sham and oestrogen-treatment controlled study with blinding for primary outcome. SETTING: KU Leuven, Belgium. SAMPLE: Twenty-four ewes METHODS: Menopause was surgically induced, after which the ewes were randomised to three groups receiving either (1) vaginal Er:YAG LASER application three times, with a one-month interval; (2) three sham manipulations with a month interval; or (3) oestrogen replacement and sham manipulations. At given intervals, ewes were clinically examined and vaginal wall biopsies taken. Vaginal compliance was determined by passive biomechanical testing from explants taken at obduction. MAIN OUTCOME MEASURES: Vaginal epithelial thickness (primary), composition of the lamina propria (collagen, elastin, glycogen and vessels content), vaginal compliance, clinical signs. RESULTS: Animals exposed to Er:YAG LASER application and sham manipulation, but not to oestrogens, displayed a significant and comparable increase in vaginal epithelial thickness between baseline and seven days after the third application (69% and 67% respectively, both p&lt;.0008). In LASER treated ewes, temporary vaginal discharge and limited thermal injury were observed. Oestrogen substituted ewes displayed a more prominent increase in epithelial thickness (202%; p&lt;.0001) and higher vaginal compliance (p &lt;.05). None of the interventions induced changes in the lamina propria. CONCLUSIONS: Vaginal Er:YAG LASER has comparable effect to sham manipulation in menopausal ewes.

Název v anglickém jazyce

Vaginal Er:YAG laser application in the menopausal ewe model: a randomised estrogen and sham-controlled trial

Popis výsledku anglicky

OBJECTIVE: To describe effects of non-ablative Er:YAG LASER on vaginal atrophy induced by iatrogenic menopause in the ewe. DESIGN: Animal experimental, randomised, sham and oestrogen-treatment controlled study with blinding for primary outcome. SETTING: KU Leuven, Belgium. SAMPLE: Twenty-four ewes METHODS: Menopause was surgically induced, after which the ewes were randomised to three groups receiving either (1) vaginal Er:YAG LASER application three times, with a one-month interval; (2) three sham manipulations with a month interval; or (3) oestrogen replacement and sham manipulations. At given intervals, ewes were clinically examined and vaginal wall biopsies taken. Vaginal compliance was determined by passive biomechanical testing from explants taken at obduction. MAIN OUTCOME MEASURES: Vaginal epithelial thickness (primary), composition of the lamina propria (collagen, elastin, glycogen and vessels content), vaginal compliance, clinical signs. RESULTS: Animals exposed to Er:YAG LASER application and sham manipulation, but not to oestrogens, displayed a significant and comparable increase in vaginal epithelial thickness between baseline and seven days after the third application (69% and 67% respectively, both p&lt;.0008). In LASER treated ewes, temporary vaginal discharge and limited thermal injury were observed. Oestrogen substituted ewes displayed a more prominent increase in epithelial thickness (202%; p&lt;.0001) and higher vaginal compliance (p &lt;.05). None of the interventions induced changes in the lamina propria. CONCLUSIONS: Vaginal Er:YAG LASER has comparable effect to sham manipulation in menopausal ewes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BJOG: An International Journal of Obstetrics &amp; Gynaecology

ISSN

1470-0328

e-ISSN

—

Svazek periodika

128

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

1087-1096

Kód UT WoS článku

000587775900001

EID výsledku v databázi Scopus

2-s2.0-85096809122