Renal involvement in Systemic Sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000062" target="_blank" >RIV/00023728:_____/19:N0000062 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/19:10406003 RIV/00179906:_____/19:10406003

Výsledek na webu

<a href="https://www.intechopen.com/books/new-insights-into-systemic-sclerosis/renal-involvement-in-systemic-sclerosis" target="_blank" >https://www.intechopen.com/books/new-insights-into-systemic-sclerosis/renal-involvement-in-systemic-sclerosis</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/intechopen.87187" target="_blank" >10.5772/intechopen.87187</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Renal involvement in Systemic Sclerosis

Popis výsledku v původním jazyce

Scleroderma renal crisis (SRC) is classical renal disease in systemic sclerosis (SSc). SRC is a relatively rare manifestation, approximately in 5% of patients. In terms of severity, manifestation in the form of SRC is the most common cause of acute organ failure. In SSc patients, SRC is defined as a new onset of accelerated arterial hypertension and rapidly progressive anuric or oliguric renal failure. SRC is primarily vascular injury with increased activity of the renin-angiotensin activity. These events lead to release or activation of cytokines and growth factors that result in the typical proliferative vascular lesions. Successful approach is routine use of angiotensin-converting enzyme inhibitors in the treatment of SRC (except prevention) and other advances in renal replacement therapy in SSc management. It is crucial to detect manifestations of SRC early and to manage appropriately in collaboration with intensive care medicine, cardiologists, and nephrologists. In contrast to SRC, clinical presentation of interstitial renal disease is poor, often without evidence of renal abnormality. Interestingly, other renal manifestations are glomerulonephritis and vasculitis. These manifestations are associated with overlapping mechanisms. The objective of this chapter is to focus on actual knowledge about the renal involvement in SSc and current treatment principles and possibilities.

Název v anglickém jazyce

Renal involvement in Systemic Sclerosis

Popis výsledku anglicky

Scleroderma renal crisis (SRC) is classical renal disease in systemic sclerosis (SSc). SRC is a relatively rare manifestation, approximately in 5% of patients. In terms of severity, manifestation in the form of SRC is the most common cause of acute organ failure. In SSc patients, SRC is defined as a new onset of accelerated arterial hypertension and rapidly progressive anuric or oliguric renal failure. SRC is primarily vascular injury with increased activity of the renin-angiotensin activity. These events lead to release or activation of cytokines and growth factors that result in the typical proliferative vascular lesions. Successful approach is routine use of angiotensin-converting enzyme inhibitors in the treatment of SRC (except prevention) and other advances in renal replacement therapy in SSc management. It is crucial to detect manifestations of SRC early and to manage appropriately in collaboration with intensive care medicine, cardiologists, and nephrologists. In contrast to SRC, clinical presentation of interstitial renal disease is poor, often without evidence of renal abnormality. Interestingly, other renal manifestations are glomerulonephritis and vasculitis. These manifestations are associated with overlapping mechanisms. The objective of this chapter is to focus on actual knowledge about the renal involvement in SSc and current treatment principles and possibilities.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30226 - Rheumatology

Projekt

<a href="/cs/project/NV16-33542A" target="_blank" >NV16-33542A: Role Hsp90 (Heat shock protein 90) u vybraných revmatických onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

New Insight into Systemic Sclerosis

ISBN

978-1-83962-204-5

Počet stran výsledku

22

Strana od-do

41-62

Počet stran knihy

148

Název nakladatele

IntechOpen

Místo vydání

London

Kód UT WoS kapitoly

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