Polyreactivity and immunoglobulin variable region gene usage in human CD5+ B cells.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F99%3A00000021" target="_blank" >RIV/00023728:_____/99:00000021 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Polyreactivity and immunoglobulin variable region gene usage in human CD5+ B cells.

Popis výsledku v původním jazyce

B-lymphocytes that express the pan T cell glycoprotein CD5 (CD5+ or B1 cells) show a variety of features that distinguish them from the bulk of conventional CD5- B cells (B2 cells). Among these are a distinctive surface phenotype and a propensity to produce antibodies that react with low avidity to multiple antigens including self-antigens (i.e.) polyreactive or natural antibodies) which could lead to pathogenic autoantibodies found in autoimmune diseases. Studies on foetal, cord blood and leukaemiaB cells, which express the CD5+ marker implied that: a) number of immunoglobulin variable region (IgV) genes are preferentially expressed in CD5+ B cells; and b) that the production of polyreactive antibodies may be an exclusive feature of CD5+ cells. Studies presented here show that whilst IgV genes in germline, or near germline, configuration that often encode natural antibodies are expressed at high frequency, in CD5+ B cells, the expression of these genes is not restricted to CD5+ B cell

Název v anglickém jazyce

Polyreactivity and immunoglobulin variable region gene usage in human CD5+ B cells.

Popis výsledku anglicky

B-lymphocytes that express the pan T cell glycoprotein CD5 (CD5+ or B1 cells) show a variety of features that distinguish them from the bulk of conventional CD5- B cells (B2 cells). Among these are a distinctive surface phenotype and a propensity to produce antibodies that react with low avidity to multiple antigens including self-antigens (i.e.) polyreactive or natural antibodies) which could lead to pathogenic autoantibodies found in autoimmune diseases. Studies on foetal, cord blood and leukaemiaB cells, which express the CD5+ marker implied that: a) number of immunoglobulin variable region (IgV) genes are preferentially expressed in CD5+ B cells; and b) that the production of polyreactive antibodies may be an exclusive feature of CD5+ cells. Studies presented here show that whilst IgV genes in germline, or near germline, configuration that often encode natural antibodies are expressed at high frequency, in CD5+ B cells, the expression of these genes is not restricted to CD5+ B cell

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

—

Projekt

<a href="/cs/project/IZ3638" target="_blank" >IZ3638: Léčba polymyositidy a dermatomyositidy methotrexatem a cyklosporinem A a nové možnosti hodnocení</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

1999

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trans-Caucasian Journal of Immunology

ISSN

—

e-ISSN

—

Svazek periodika

1

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GE - Gruzie

Počet stran výsledku

18

Strana od-do

—

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—