The presence of clonal granulocyte and CD14+ subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with "pure" refractory anemia may reflect a multistep pathogenesis of my

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F03%3A00000084" target="_blank" >RIV/00023736:_____/03:00000084 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

The presence of clonal granulocyte and CD14+ subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with "pure" refractory anemia may reflect a multistep pathogenesis of my

Popis výsledku v původním jazyce

Clonality assay based on investigation of X-chromosome inactivation patterns of HUMARA gene was performed in 29 female patients with primary MDS. Peripheral blood clonal granulocytes were present in 11 out of 12 patients with RCMD in contrast to only 1 out of 7 females with RA according to the WHO classification. Similar results were found in CD 14+ subpopulation in peripheral blood and in both subpopulations in bone marrow. Patients with clonal subpopulations had significantly poorer prognosis than those with non-clonal subpopulations.

Název v anglickém jazyce

The presence of clonal granulocyte and CD14+ subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with "pure" refractory anemia may reflect a multistep pathogenesis of my

Popis výsledku anglicky

Clonality assay based on investigation of X-chromosome inactivation patterns of HUMARA gene was performed in 29 female patients with primary MDS. Peripheral blood clonal granulocytes were present in 11 out of 12 patients with RCMD in contrast to only 1 out of 7 females with RA according to the WHO classification. Similar results were found in CD 14+ subpopulation in peripheral blood and in both subpopulations in bone marrow. Patients with clonal subpopulations had significantly poorer prognosis than those with non-clonal subpopulations.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NK7713" target="_blank" >NK7713: Význam vyšetření klonality pro diagnosu, prognosu a léčebné ovlivnění myelodysplastického syndromu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Blood

ISSN

0006-4971

e-ISSN

—

Svazek periodika

102

Číslo periodika v rámci svazku

11, S1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

"915a"-915a"

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—