Targeting the cleavage factor and polyadenylation signal of pre-mRNA as methods for silencing the causative gene of the disease

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F19%3A00012656" target="_blank" >RIV/00023736:_____/19:00012656 - isvavai.cz</a>
Výsledek na webu
<a href="https://novapublishers.com/shop/a-closer-look-at-polyadenylation/" target="_blank" >https://novapublishers.com/shop/a-closer-look-at-polyadenylation/</a>
DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Targeting the cleavage factor and polyadenylation signal of pre-mRNA as methods for silencing the causative gene of the disease
Popis výsledku v původním jazyce
The majority of eukaryotic mRNAs are polyadenylated at their 3´end. This poly(A) tail is not encoded by DNA and is added cotranscriptionally. Cleavage and polyadenylation specific factor (CPSF1) is part of multiple subunit factors required for a site-specific cleavage, which is involved in determining specificity and efficiency of the 3´end processing of pre-mRNAs in the nucleus by recognizing teh polyadenylation signal
Název v anglickém jazyce
Targeting the cleavage factor and polyadenylation signal of pre-mRNA as methods for silencing the causative gene of the disease
Popis výsledku anglicky
The majority of eukaryotic mRNAs are polyadenylated at their 3´end. This poly(A) tail is not encoded by DNA and is added cotranscriptionally. Cleavage and polyadenylation specific factor (CPSF1) is part of multiple subunit factors required for a site-specific cleavage, which is involved in determining specificity and efficiency of the 3´end processing of pre-mRNAs in the nucleus by recognizing teh polyadenylation signal

Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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