The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000289" target="_blank" >RIV/00209805:_____/12:#0000289 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.landesbioscience.com/journals/rnabiology/article/20231/?nocache=598305625" target="_blank" >http://www.landesbioscience.com/journals/rnabiology/article/20231/?nocache=598305625</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4161/rna.20231" target="_blank" >10.4161/rna.20231</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells
Popis výsledku v původním jazyce
The untranslated regions (UTRs) at the 3' end of mRNA transcripts contain important sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we summarize the information known to date about 3' end processing, sequence characteristics including related binding proteins and the role of 3' UTRs in several selected signaling pathways to delineate their importance in the regulatory processes in mammalian cells. In addition to reviewing recent advances in the more well-known aspects, such as cleavage and polyadenylation processes that influence mRNA stability and location, we concentrate on some newly emerging concepts of the role of the 3' UTR, including alternative polyadenylation sites in relation to proliferation and differentiation and the recognition of the multi-functional properties of noncoding RNAs, including miRNAs that commonly target the 3' UTR. The emerging picture is of a highly complex set of regulatory systems that include autoregulation, cooperati
Název v anglickém jazyce
The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells
Popis výsledku anglicky
The untranslated regions (UTRs) at the 3' end of mRNA transcripts contain important sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we summarize the information known to date about 3' end processing, sequence characteristics including related binding proteins and the role of 3' UTRs in several selected signaling pathways to delineate their importance in the regulatory processes in mammalian cells. In addition to reviewing recent advances in the more well-known aspects, such as cleavage and polyadenylation processes that influence mRNA stability and location, we concentrate on some newly emerging concepts of the role of the 3' UTR, including alternative polyadenylation sites in relation to proliferation and differentiation and the recognition of the multi-functional properties of noncoding RNAs, including miRNAs that commonly target the 3' UTR. The emerging picture is of a highly complex set of regulatory systems that include autoregulation, cooperati
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
RNA biology
ISSN
1547-6286
e-ISSN
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Svazek periodika
9
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
14
Strana od-do
563-576
Kód UT WoS článku
000306528800009
EID výsledku v databázi Scopus
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