Identifying risk factors and optimizing standard of care for patients with acquired haemophilia A: results from a Czech patient cohort

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F20%3A00013037" target="_blank" >RIV/00023736:_____/20:00013037 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/20:10414179

Výsledek na webu

<a href="https://doi.org/10.1111/hae.14084" target="_blank" >https://doi.org/10.1111/hae.14084</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/hae.14084" target="_blank" >10.1111/hae.14084</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identifying risk factors and optimizing standard of care for patients with acquired haemophilia A: results from a Czech patient cohort

Popis výsledku v původním jazyce

Acquired haemophilia A (AHA) is a rare autoimmune disorder, characterized by bleeds of varying severity caused by autoantibodies against factor VIII (FVIII). Identify risk factors associated with AHA-related deaths/relapses and assess the effect of increased corticosteroid doses. AHA patients treated across two specialist centres in the Czech Republic, generally receiving first-line haemostatic therapy with rFVIIa and immunosuppression with corticosteroids/cyclophosphamide, were included. We analysed the association between early death (within 8 weeks of diagnosis [considered disease-related]) and age, malignancy, FVIII levels and bleeding severity. Risk factors associated with reduced 2-year survival and relapse incidence, and the effect of increased corticosteroid doses on early death and remission were also assessed.

Název v anglickém jazyce

Identifying risk factors and optimizing standard of care for patients with acquired haemophilia A: results from a Czech patient cohort

Popis výsledku anglicky

Acquired haemophilia A (AHA) is a rare autoimmune disorder, characterized by bleeds of varying severity caused by autoantibodies against factor VIII (FVIII). Identify risk factors associated with AHA-related deaths/relapses and assess the effect of increased corticosteroid doses. AHA patients treated across two specialist centres in the Czech Republic, generally receiving first-line haemostatic therapy with rFVIIa and immunosuppression with corticosteroids/cyclophosphamide, were included. We analysed the association between early death (within 8 weeks of diagnosis [considered disease-related]) and age, malignancy, FVIII levels and bleeding severity. Risk factors associated with reduced 2-year survival and relapse incidence, and the effect of increased corticosteroid doses on early death and remission were also assessed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Haemophilia

ISSN

1351-8216

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

643-651

Kód UT WoS článku

000543243500001

EID výsledku v databázi Scopus

2-s2.0-85087172640