ABCB1 amplicon contains cyclic AMP response element-driven TRIP6 gene in taxane-resistant MCF-7 breast cancer sublines

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F23%3A00013518" target="_blank" >RIV/00023736:_____/23:00013518 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/75010330:_____/23:00014188 RIV/00216208:11120/23:43925160 RIV/00216208:11310/23:10457078 RIV/00216208:11140/23:10457078

Výsledek na webu

<a href="https://doi.org/10.3390/genes14020296" target="_blank" >https://doi.org/10.3390/genes14020296</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/genes14020296" target="_blank" >10.3390/genes14020296</a>

Jazyk výsledku

angličtina

Název v původním jazyce

ABCB1 amplicon contains cyclic AMP response element-driven TRIP6 gene in taxane-resistant MCF-7 breast cancer sublines

Popis výsledku v původním jazyce

A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant MCF-7 sublines (manifesting even higher TRIP6 expression). We found that TRIP6 transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells. Furthermore, in taxane-resistant MCF-7 sublines, TRIP6 co-amplification with the neighboring ABCB1 gene, as witnessed by fluorescence in situ hybridization (FISH), led to TRIP6 overexpression. Ultimately, we found high TRIP6 mRNA levels in progesterone receptor-positive breast cancer and samples resected from premenopausal women.

Název v anglickém jazyce

ABCB1 amplicon contains cyclic AMP response element-driven TRIP6 gene in taxane-resistant MCF-7 breast cancer sublines

Popis výsledku anglicky

A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant MCF-7 sublines (manifesting even higher TRIP6 expression). We found that TRIP6 transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells. Furthermore, in taxane-resistant MCF-7 sublines, TRIP6 co-amplification with the neighboring ABCB1 gene, as witnessed by fluorescence in situ hybridization (FISH), led to TRIP6 overexpression. Ultimately, we found high TRIP6 mRNA levels in progesterone receptor-positive breast cancer and samples resected from premenopausal women.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Genes

ISSN

2073-4425

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

23

Strana od-do

"art. no. 296"

Kód UT WoS článku

000944841000001

EID výsledku v databázi Scopus

2-s2.0-85148869540