Phenotype and oxidative burst of low-density neutrophil subpopulations are altered in common variable immunodeficiency patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013584" target="_blank" >RIV/00023736:_____/24:00013584 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/cyto.b.22150" target="_blank" >https://doi.org/10.1002/cyto.b.22150</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cyto.b.22150" target="_blank" >10.1002/cyto.b.22150</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phenotype and oxidative burst of low-density neutrophil subpopulations are altered in common variable immunodeficiency patients

Popis výsledku v původním jazyce

Common variable immunodeficiency disorder (CVID) is the most common form of primary antibody immunodeficiency. Due to low antibody levels, CVID patients receive intravenous or subcutaneous immunoglobulin replacement therapy as treatment. CVID is associated with the chronic activation of granulocytes, including an increased percentage of low-density neutrophils (LDNs). In this study, we examined changes in the percentage of LDNs and the expression of their surface markers in 25 patients with CVID and 27 healthy donors (HD) after in vitro stimulation of whole blood using IVIg. An oxidative burst assay was used to assess the functionality of LDNs.

Název v anglickém jazyce

Phenotype and oxidative burst of low-density neutrophil subpopulations are altered in common variable immunodeficiency patients

Popis výsledku anglicky

Common variable immunodeficiency disorder (CVID) is the most common form of primary antibody immunodeficiency. Due to low antibody levels, CVID patients receive intravenous or subcutaneous immunoglobulin replacement therapy as treatment. CVID is associated with the chronic activation of granulocytes, including an increased percentage of low-density neutrophils (LDNs). In this study, we examined changes in the percentage of LDNs and the expression of their surface markers in 25 patients with CVID and 27 healthy donors (HD) after in vitro stimulation of whole blood using IVIg. An oxidative burst assay was used to assess the functionality of LDNs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cytometry part B: clinical cytometry

ISSN

0196-4763

e-ISSN

—

Svazek periodika

106

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

99-112

Kód UT WoS článku

001109148500001

EID výsledku v databázi Scopus

2-s2.0-85177603270