Mass-spectrometric identification of proteins and pathways responsible for fouling on poly(ethylene glycol) methacrylate polymer brushes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013642" target="_blank" >RIV/00023736:_____/24:00013642 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/24:00586901 RIV/60076658:12310/24:43908824

Výsledek na webu

<a href="https://doi.org/10.1002/mabi.202300558" target="_blank" >https://doi.org/10.1002/mabi.202300558</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mabi.202300558" target="_blank" >10.1002/mabi.202300558</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mass-spectrometric identification of proteins and pathways responsible for fouling on poly(ethylene glycol) methacrylate polymer brushes

Popis výsledku v původním jazyce

Prevention of fouling from proteins in blood plasma attracts significant efforts, and great progress is made in identifying surface coatings that display antifouling properties. In particular, poly(ethylene glycol) (PEG) is widely used and dense PEG-like cylindrical brushes of poly[oligo(ethylene glycol) methacrylate] (poly(OEGMA)) can drastically reduce blood plasma fouling. Herein, a comprehensive study of the variation of blood plasma fouling on this surface, including the analysis of the composition of protein deposits on poly(OEGMA) coatings after contact with blood plasma from many different donors, is reported. Correlation between the plasma fouling behavior and protein deposit composition points to the activation of the complement system as the main culprit of dramatically increased and accelerated deposition of blood plasma proteins on this type of antifouling coating, specifically through the classical pathway. These findings are consistent with observations on PEGylated drug carriers and highlight the importance of understanding the potential interactions between antifouling coatings and their environment.

Název v anglickém jazyce

Mass-spectrometric identification of proteins and pathways responsible for fouling on poly(ethylene glycol) methacrylate polymer brushes

Popis výsledku anglicky

Prevention of fouling from proteins in blood plasma attracts significant efforts, and great progress is made in identifying surface coatings that display antifouling properties. In particular, poly(ethylene glycol) (PEG) is widely used and dense PEG-like cylindrical brushes of poly[oligo(ethylene glycol) methacrylate] (poly(OEGMA)) can drastically reduce blood plasma fouling. Herein, a comprehensive study of the variation of blood plasma fouling on this surface, including the analysis of the composition of protein deposits on poly(OEGMA) coatings after contact with blood plasma from many different donors, is reported. Correlation between the plasma fouling behavior and protein deposit composition points to the activation of the complement system as the main culprit of dramatically increased and accelerated deposition of blood plasma proteins on this type of antifouling coating, specifically through the classical pathway. These findings are consistent with observations on PEGylated drug carriers and highlight the importance of understanding the potential interactions between antifouling coatings and their environment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecular bioscience

ISSN

1616-5187

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

"art. no. 2300558"

Kód UT WoS článku

001173158300001

EID výsledku v databázi Scopus

2-s2.0-85185970697