Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F03%3A00000282" target="_blank" >RIV/00023752:_____/03:00000282 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801

Popis výsledku v původním jazyce

Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect.

Název v anglickém jazyce

Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801

Popis výsledku anglicky

Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatrie

ISSN

1211-7579

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

Suppl. 3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

50-54

Kód UT WoS článku

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EID výsledku v databázi Scopus

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