Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia

Popis výsledku v původním jazyce

Destabilization of intracellular calcium homeostasis in neurons has been implicated in the pathogenesis of Alzheimer´s dementia (AD). In this study the disturbed calcium homeostasis was examined in platelets of AD patients during the course of the disease and on individual basis. There were no significant differences in calcium homeostasis between mild, moderate and severe stages of AD (n=46), but significant changes were found in all AD stages compared to age-matched nondemented control subjects (n=18). In individual, long term monitored AD patients, the percentage of increase in platelet free intracellular calcium level, in the presence of 1mM calcium in the incubation medium above the basal value, decreased with the progression of the disease in allcases (n=6).

Název v anglickém jazyce

Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia

Popis výsledku anglicky

Destabilization of intracellular calcium homeostasis in neurons has been implicated in the pathogenesis of Alzheimer´s dementia (AD). In this study the disturbed calcium homeostasis was examined in platelets of AD patients during the course of the disease and on individual basis. There were no significant differences in calcium homeostasis between mild, moderate and severe stages of AD (n=46), but significant changes were found in all AD stages compared to age-matched nondemented control subjects (n=18). In individual, long term monitored AD patients, the percentage of increase in platelet free intracellular calcium level, in the presence of 1mM calcium in the incubation medium above the basal value, decreased with the progression of the disease in allcases (n=6).

Druh

C - Kapitola v odborné knize

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

New Trends in Alzheimer and Parkinson Related Disorders

ISBN

88-7587-023-3

Počet stran výsledku

4

Strana od-do

53-56

Počet stran knihy

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Název nakladatele

Monduzzi Editore

Místo vydání

Bologna

Kód UT WoS kapitoly

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