Analýza enhancerové oblasti genu pro protocadherin alfa u pacientů s bipolární poruchou a schizofrenií

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F08%3A00000909" target="_blank" >RIV/00023752:_____/08:00000909 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia

Popis výsledku v původním jazyce

Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linkedPCDH family, which consists of more than 50 exons encoding three related, though distinct family members ? á, â, and ă ? which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. Inthis study, we focused on a SNP, rs31745, which is located in a putative PCDHá enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3. A striking increase in homozygotes for the minor allele at this locus was det

Název v anglickém jazyce

Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia

Popis výsledku anglicky

Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linkedPCDH family, which consists of more than 50 exons encoding three related, though distinct family members ? á, â, and ă ? which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. Inthis study, we focused on a SNP, rs31745, which is located in a putative PCDHá enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3. A striking increase in homozygotes for the minor allele at this locus was det

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR8564" target="_blank" >NR8564: Role fosfoinositidové dráhy v rozvoji bipolární afektivní poruchy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Schizophrenia Research

ISSN

0920-9964

e-ISSN

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Svazek periodika

102

Číslo periodika v rámci svazku

1-3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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