Analýza delece v genu pro protocadherin alfa u pacientů s bipolární poruchou a schizofrenií

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F08%3A00000912" target="_blank" >RIV/00023752:_____/08:00000912 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia

Popis výsledku v původním jazyce

The cell adhesion proteins cadherins and protocadherins, through their effects on neuronal differentiation, synaptogenesis, and brain development, are feasible targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider as underlying susceptibility factors. One such set of candidate genes is the 5q31-linked PCDH family. A polymorphic copy number variation in this locus, a 16.7 kilobase (kb) deletion affecting PCDH-? exons 8-10 (?8-?10?), was analyzed in this study in a cohort of European Caucasian patients with SZ and a cohort of patients with BD from the Czech Republic, and corresponding controls. No differences in allele distribution were detected in either group. While theoretical considerations and linkage studies suggest that the 5q31-linked PCDH genes should be viewed a

Název v anglickém jazyce

Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia

Popis výsledku anglicky

The cell adhesion proteins cadherins and protocadherins, through their effects on neuronal differentiation, synaptogenesis, and brain development, are feasible targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider as underlying susceptibility factors. One such set of candidate genes is the 5q31-linked PCDH family. A polymorphic copy number variation in this locus, a 16.7 kilobase (kb) deletion affecting PCDH-? exons 8-10 (?8-?10?), was analyzed in this study in a cohort of European Caucasian patients with SZ and a cohort of patients with BD from the Czech Republic, and corresponding controls. No differences in allele distribution were detected in either group. While theoretical considerations and linkage studies suggest that the 5q31-linked PCDH genes should be viewed a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatric Genetics

ISSN

0955-8829

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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