Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F13%3A43914190" target="_blank" >RIV/00023752:_____/13:43914190 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/13:#0000391

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0960076012001525" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0960076012001525</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jsbmb.2012.08.009" target="_blank" >10.1016/j.jsbmb.2012.08.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia

Popis výsledku v původním jazyce

Metabolomic studies represent a promising tool for early diagnosis of schizophrenia. The aim of this study was to find differences in the steroid spectrum in patients and controls, and to assess the diagnosis of schizophrenia by building a predictive model based on steroid data. Thirty-nine serum steroids (22 neuroactive steroids and their metabolites and 17 polar conjugates) were measured by gas chromatography-mass spectrometry in 22 drug-naive (first episode) schizophrenia patients before and after six-month treatment with atypical antipsychotics and in 47 healthy subjects. In summary the following significant differences were found: In both sexes higher levels of pregnenolone sulfate and sulfated 5 alpha- as well as 5 beta-saturated metabolites of C21-steroids in progesterone metabolic pathway were found in patients, pointing to decreased activity of sulfatase. In a few instances decreased levels of the respective 5 alpha-metabolites of C21 steroids were found in patients. As C19 st

Název v anglickém jazyce

Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia

Popis výsledku anglicky

Metabolomic studies represent a promising tool for early diagnosis of schizophrenia. The aim of this study was to find differences in the steroid spectrum in patients and controls, and to assess the diagnosis of schizophrenia by building a predictive model based on steroid data. Thirty-nine serum steroids (22 neuroactive steroids and their metabolites and 17 polar conjugates) were measured by gas chromatography-mass spectrometry in 22 drug-naive (first episode) schizophrenia patients before and after six-month treatment with atypical antipsychotics and in 47 healthy subjects. In summary the following significant differences were found: In both sexes higher levels of pregnenolone sulfate and sulfated 5 alpha- as well as 5 beta-saturated metabolites of C21-steroids in progesterone metabolic pathway were found in patients, pointing to decreased activity of sulfatase. In a few instances decreased levels of the respective 5 alpha-metabolites of C21 steroids were found in patients. As C19 st

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NT13890" target="_blank" >NT13890: Úloha neuroaktivních steroidů v etiopatogenezi afektivních a úzkostných poruch</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Steroid Biochemistry and Molecular Biology

ISSN

0960-0760

e-ISSN

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Svazek periodika

133

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

77-83

Kód UT WoS článku

000313296600009

EID výsledku v databázi Scopus

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