Exploring the relationship between endogenous steroids and nausea and vomiting in pregnancy: A longitudinal prospective study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F26%3AW0000028" target="_blank" >RIV/00064211:_____/26:W0000028 - isvavai.cz</a>

Výsledek na webu

<a href="https://dx.doi.org/10.1016/j.steroids.2025.109701" target="_blank" >https://dx.doi.org/10.1016/j.steroids.2025.109701</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.steroids.2025.109701" target="_blank" >10.1016/j.steroids.2025.109701</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exploring the relationship between endogenous steroids and nausea and vomiting in pregnancy: A longitudinal prospective study

Popis výsledku v původním jazyce

Nausea and vomiting in pregnancy (NVP) affect approximately 70 % of women worldwide. It is thought to have an adaptive function in the first trimester, when it protects the mother and the fetus against potential dangers from the diet. Proximate causes of NVP include hormonal changes during pregnancy. This longitudinal prospective study examined associations between various endogenous steroids and NVP. In the first and third trimester, pregnant women (N = 179) completed the Index of Nausea, Vomiting, and Retching questionnaire (92.1 % of women reported at least some symptoms of NVP in the first trimester and 37.4 % in the third trimester) and we analyzed their blood serum concentrations of 91 endogenous steroids. In the first trimester, NVP intensity was significantly positively associated with progesterone metabolites from the C21 5 alpha/beta-reduced steroid group (e.g., allopregnanolone sulfate) and with conjugated 5 alpha-androstane-3 alpha,17 beta-diol and conjugated 5 alpha androstane-3 beta,17 beta-diol. In the third trimester, we found significant negative associations between NVP and progesterone, conjugated testosterone, 7-oxo-DHEA, 5-androstene-3 beta,16 alpha,17 beta-triol sulfate, some C21 Delta 5 steroids (e.g., pregnenolone sulfate, 17-hydroxypregnenolone sulfate), and C21 5 alpha/beta-reduced steroids (such as allopregnanolone sulfate and conjugated pregnanolone). Our findings suggest that sulfated 3 alpha-hydroxy-5 alpha-steroids may contribute to NVP in early pregnancy by affecting brainstem regions involved in the vomiting reflex. In late pregnancy, higher levels of immunomodulatory androstanes and progesterone may reduce NVP severity via immune regulation and smooth muscle relaxation.

Název v anglickém jazyce

Exploring the relationship between endogenous steroids and nausea and vomiting in pregnancy: A longitudinal prospective study

Popis výsledku anglicky

Nausea and vomiting in pregnancy (NVP) affect approximately 70 % of women worldwide. It is thought to have an adaptive function in the first trimester, when it protects the mother and the fetus against potential dangers from the diet. Proximate causes of NVP include hormonal changes during pregnancy. This longitudinal prospective study examined associations between various endogenous steroids and NVP. In the first and third trimester, pregnant women (N = 179) completed the Index of Nausea, Vomiting, and Retching questionnaire (92.1 % of women reported at least some symptoms of NVP in the first trimester and 37.4 % in the third trimester) and we analyzed their blood serum concentrations of 91 endogenous steroids. In the first trimester, NVP intensity was significantly positively associated with progesterone metabolites from the C21 5 alpha/beta-reduced steroid group (e.g., allopregnanolone sulfate) and with conjugated 5 alpha-androstane-3 alpha,17 beta-diol and conjugated 5 alpha androstane-3 beta,17 beta-diol. In the third trimester, we found significant negative associations between NVP and progesterone, conjugated testosterone, 7-oxo-DHEA, 5-androstene-3 beta,16 alpha,17 beta-triol sulfate, some C21 Delta 5 steroids (e.g., pregnenolone sulfate, 17-hydroxypregnenolone sulfate), and C21 5 alpha/beta-reduced steroids (such as allopregnanolone sulfate and conjugated pregnanolone). Our findings suggest that sulfated 3 alpha-hydroxy-5 alpha-steroids may contribute to NVP in early pregnancy by affecting brainstem regions involved in the vomiting reflex. In late pregnancy, higher levels of immunomodulatory androstanes and progesterone may reduce NVP severity via immune regulation and smooth muscle relaxation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2026

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

STEROIDS

ISSN

0039-128X

e-ISSN

1878-5867

Svazek periodika

225

Číslo periodika v rámci svazku

JAN 2026

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

-

Kód UT WoS článku

001623471300001

EID výsledku v databázi Scopus

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