EEG and neurocognitive changes in chronic methamphetamine abuse

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F14%3A43914660" target="_blank" >RIV/00023752:_____/14:43914660 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11210/14:10296348

Výsledek na webu

<a href="http://austinpublishinggroup.org/psychiatry-behavioral-sciences/fulltext/ajpbs-v1-id1024.php#Top" target="_blank" >http://austinpublishinggroup.org/psychiatry-behavioral-sciences/fulltext/ajpbs-v1-id1024.php#Top</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EEG and neurocognitive changes in chronic methamphetamine abuse

Popis výsledku v původním jazyce

Methamphetamine is a potent and highly addictive psychostimulant that has become very popular on the illicit drug market. There is a large amount of literature regarding the neurocognitive changes associated with chronic methamphetamine exposure that are present in currently abstinent individuals. However, the evidence about the possible reversibility of such changes is less clear and only sparse data exists concerning the electroencephalographic (EEG) changes in methamphetamine users. We present a case of a 38 year old male with a 10 year history of continuous abuse of high doses of methamphetamine. The patient has been incapable of adequate social functioning for the last two years and during that period has also been repeatedly admitted to a psychiatric ward due to methamphetamine associated aggressive behavior. After 25 days of abstinence, neurocognitive testing revealed mild cognitive impairment that was most pronounced in psychomotor speed and sequencing in working memory. EEG assessment performed by both visual inspection and quantitative EEG brain mapping showed a slowing of the frequency of dominant occipital activity to the sub alpha frequency band as well as an increase of theta power. No pathological findings were seen on the Magnetic resonance imaging of the brain, however, repeated EEG 20 days later confirmed an abnormal slowing of the dominant alpha frequency. Our findings are in accordance with the limited data available in the literature. However, further studies are needed to confirm the utility of EEG as a marker of methamphetamine toxicity, as well as the association between EEG findings and the neurocognitive performance and the reversibility of both variables in the case of sustained abstinence.

Název v anglickém jazyce

EEG and neurocognitive changes in chronic methamphetamine abuse

Popis výsledku anglicky

Methamphetamine is a potent and highly addictive psychostimulant that has become very popular on the illicit drug market. There is a large amount of literature regarding the neurocognitive changes associated with chronic methamphetamine exposure that are present in currently abstinent individuals. However, the evidence about the possible reversibility of such changes is less clear and only sparse data exists concerning the electroencephalographic (EEG) changes in methamphetamine users. We present a case of a 38 year old male with a 10 year history of continuous abuse of high doses of methamphetamine. The patient has been incapable of adequate social functioning for the last two years and during that period has also been repeatedly admitted to a psychiatric ward due to methamphetamine associated aggressive behavior. After 25 days of abstinence, neurocognitive testing revealed mild cognitive impairment that was most pronounced in psychomotor speed and sequencing in working memory. EEG assessment performed by both visual inspection and quantitative EEG brain mapping showed a slowing of the frequency of dominant occipital activity to the sub alpha frequency band as well as an increase of theta power. No pathological findings were seen on the Magnetic resonance imaging of the brain, however, repeated EEG 20 days later confirmed an abnormal slowing of the dominant alpha frequency. Our findings are in accordance with the limited data available in the literature. However, further studies are needed to confirm the utility of EEG as a marker of methamphetamine toxicity, as well as the association between EEG findings and the neurocognitive performance and the reversibility of both variables in the case of sustained abstinence.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30215 - Psychiatry

Projekt

<a href="/cs/project/NT13897" target="_blank" >NT13897: Animální a humánní serotonergní model schizofrenie: validita hodnocená pomocí qEEG a fMRI.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Austin Journal of Psychiatry and Behavioral Sciences

ISSN

2381-9006

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

1-3

Kód UT WoS článku

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EID výsledku v databázi Scopus

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