Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43914895" target="_blank" >RIV/00023752:_____/16:43914895 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/16:00243229 RIV/00216208:11110/16:10324199 RIV/00064165:_____/16:10324199

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1389945715009296" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1389945715009296</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sleep.2015.07.030" target="_blank" >10.1016/j.sleep.2015.07.030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder

Popis výsledku v původním jazyce

Objective: Patients with idiopathic rapid eye movement sleep behaviour disorder (RBD) are at substantial risk for developing Parkinson's disease (PD) or related neurodegenerative disorders. Speech is an important indicator of motor function and movement coordination, and therefore may be an extremely sensitive early marker of changes due to prodromal neurodegeneration. Methods: Speech data were acquired from 16 RBD subjects and 16 age- and sex-matched healthy control subjects. Objective acoustic assessment of 15 speech dimensions representing various phonatory, articulatory, and prosodic deviations was performed. Statistical models were applied to characterise speech disorders in RBD and to estimate sensitivity and specificity in differentiating between RBD and control subjects. Results: Some form of speech impairment was revealed in 88% of RBD subjects. Articulatory deficits were the most prominent findings in RBD. In comparison to controls, the RBD group showed significant alterations in irregular alternatingmotion rates (p = 0.009) and articulatory decay (p = 0.01). The combination of four distinctive speech dimensions, including aperiodicity, irregular alternating motion rates, articulatory decay, and dysfluency, led to 96% sensitivity and 79% specificity in discriminating between RBD and control subjects. Speech impairment was significantly more pronounced in RBD subjects with the motor score of the Unified Parkinson's Disease Rating Scale greater than 4 points when compared to other RBD individuals. Conclusion: Simple quantitative speech motor measures may be suitable for the reliable detection of prodromal neurodegeneration in subjects with RBD, and thereforemay provide important outcomes for future therapy trials.

Název v anglickém jazyce

Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder

Popis výsledku anglicky

Objective: Patients with idiopathic rapid eye movement sleep behaviour disorder (RBD) are at substantial risk for developing Parkinson's disease (PD) or related neurodegenerative disorders. Speech is an important indicator of motor function and movement coordination, and therefore may be an extremely sensitive early marker of changes due to prodromal neurodegeneration. Methods: Speech data were acquired from 16 RBD subjects and 16 age- and sex-matched healthy control subjects. Objective acoustic assessment of 15 speech dimensions representing various phonatory, articulatory, and prosodic deviations was performed. Statistical models were applied to characterise speech disorders in RBD and to estimate sensitivity and specificity in differentiating between RBD and control subjects. Results: Some form of speech impairment was revealed in 88% of RBD subjects. Articulatory deficits were the most prominent findings in RBD. In comparison to controls, the RBD group showed significant alterations in irregular alternatingmotion rates (p = 0.009) and articulatory decay (p = 0.01). The combination of four distinctive speech dimensions, including aperiodicity, irregular alternating motion rates, articulatory decay, and dysfluency, led to 96% sensitivity and 79% specificity in discriminating between RBD and control subjects. Speech impairment was significantly more pronounced in RBD subjects with the motor score of the Unified Parkinson's Disease Rating Scale greater than 4 points when compared to other RBD individuals. Conclusion: Simple quantitative speech motor measures may be suitable for the reliable detection of prodromal neurodegeneration in subjects with RBD, and thereforemay provide important outcomes for future therapy trials.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NV15-28038A" target="_blank" >NV15-28038A: Poruchy řeči a analýza jejich mechanismů u Parkinsonovy nemoci a dalších extrapyramidových onemocnění.</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sleep Medicine

ISSN

1389-9457

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

141-147

Kód UT WoS článku

000376518600023

EID výsledku v databázi Scopus

2-s2.0-84944145527