The mini-mental state examination: Czech norms and cutoffs for mild dementia and mild cognitive impairment due to Alzheimer's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915149" target="_blank" >RIV/00023752:_____/16:43915149 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/16:43912197 RIV/00064173:_____/16:N0000103

Výsledek na webu

<a href="http://www.karger.com/Article/FullText/446426" target="_blank" >http://www.karger.com/Article/FullText/446426</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000446426" target="_blank" >10.1159/000446426</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The mini-mental state examination: Czech norms and cutoffs for mild dementia and mild cognitive impairment due to Alzheimer's disease

Popis výsledku v původním jazyce

Background: There is a lack of normative studies of the Mini-Mental State Examination (MMSE) for comparison with early Alzheimer's disease (AD) according to new diagnostic criteria. Participants and Methods: We administered the MMSE to normal elderly Czechs and to patients with mild cognitive impairment (MCI) and mild dementia due to AD according to NIA-AA criteria. Results: We established percentile- and standard deviation-based norms for the MMSE from 650 normal seniors (age 69 +- 8 years, education 14 +- 3 years, MMSE score 28 +- 2 points) stratified by education and age. Dementia patients scored significantly lower than the MCI patients and both groups (110 early AD patients) had significantly lower MMSE scores than the normal seniors (22 +- 5 or 25 +- 3 vs. 28 +- 2 points) (p < 0.01). The optimal cutoff was LESS-THAN OR EQUAL TO27 points with sensitivity of 86% and specificity of 79% for early detection of AD patients. Conclusion: We provided MMSE norms, several cutoffs, and higher cutoff scores for early AD using recent guidelines.

Název v anglickém jazyce

The mini-mental state examination: Czech norms and cutoffs for mild dementia and mild cognitive impairment due to Alzheimer's disease

Popis výsledku anglicky

Background: There is a lack of normative studies of the Mini-Mental State Examination (MMSE) for comparison with early Alzheimer's disease (AD) according to new diagnostic criteria. Participants and Methods: We administered the MMSE to normal elderly Czechs and to patients with mild cognitive impairment (MCI) and mild dementia due to AD according to NIA-AA criteria. Results: We established percentile- and standard deviation-based norms for the MMSE from 650 normal seniors (age 69 +- 8 years, education 14 +- 3 years, MMSE score 28 +- 2 points) stratified by education and age. Dementia patients scored significantly lower than the MCI patients and both groups (110 early AD patients) had significantly lower MMSE scores than the normal seniors (22 +- 5 or 25 +- 3 vs. 28 +- 2 points) (p < 0.01). The optimal cutoff was LESS-THAN OR EQUAL TO27 points with sensitivity of 86% and specificity of 79% for early detection of AD patients. Conclusion: We provided MMSE norms, several cutoffs, and higher cutoff scores for early AD using recent guidelines.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/NT13183" target="_blank" >NT13183: Krátké psychometrické metody ke včasné diagnostice Alzheimerovy nemoci u seniorské populace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dementia and Geriatric Cognitive Disorders

ISSN

1420-8008

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

50-57

Kód UT WoS článku

000384738900006

EID výsledku v databázi Scopus

2-s2.0-84983756985