Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F18%3AN0000182" target="_blank" >RIV/00064173:_____/18:N0000182 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/18:43919699 RIV/00216208:11120/18:43917368

Výsledek na webu

<a href="https://doi.org/10.1159/000494489" target="_blank" >https://doi.org/10.1159/000494489</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000494489" target="_blank" >10.1159/000494489</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons

Popis výsledku v původním jazyce

BACKGROUND: The Czech version of the Montreal Cognitive Assessment (MoCA-CZ) and delayed recall of 5 words have not been validated in patients with mild cognitive impairment (MCI) due to Alzheimer disease (AD) and compared to norms of a large population. METHOD: The MoCA-CZ was administered to 1,600 elderly individuals in 2 groups consisting of 48 patients with MCI due to AD (AD-MCI) and 1,552 normal elderly adults. RESULTS: MoCA-CZ scores were significantly lower in the AD-MCI patients than in the normal elderly (21 +- 4 vs. 26 +- 3 points; p = 0.03). Under the recommended cutoff score of LESS-THAN OR EQUAL TO25, the MoCA-CZ demonstrated an excellent sensitivity of 94% but a low specificity of 62%. When the score was reduced to LESS-THAN OR EQUAL TO24, the MoCA-CZ showed an optimal sensitivity of 87% for AD-MCI and a specificity of 72%. Normal elderly persons should recall at least 2 words after delay (sensitivity 80%, specificity 74%). Several cutoff points were derived from normative data stratified by age and education. CONCLUSIONS: The cutoff for AD-MCI and stratified norms are available for the MoCA total score and delayed recall of the Czech version. The cut-off scores of the MoCA-CZ, sensitivity, and specificity are lower than in the original study.

Název v anglickém jazyce

Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons

Popis výsledku anglicky

BACKGROUND: The Czech version of the Montreal Cognitive Assessment (MoCA-CZ) and delayed recall of 5 words have not been validated in patients with mild cognitive impairment (MCI) due to Alzheimer disease (AD) and compared to norms of a large population. METHOD: The MoCA-CZ was administered to 1,600 elderly individuals in 2 groups consisting of 48 patients with MCI due to AD (AD-MCI) and 1,552 normal elderly adults. RESULTS: MoCA-CZ scores were significantly lower in the AD-MCI patients than in the normal elderly (21 +- 4 vs. 26 +- 3 points; p = 0.03). Under the recommended cutoff score of LESS-THAN OR EQUAL TO25, the MoCA-CZ demonstrated an excellent sensitivity of 94% but a low specificity of 62%. When the score was reduced to LESS-THAN OR EQUAL TO24, the MoCA-CZ showed an optimal sensitivity of 87% for AD-MCI and a specificity of 72%. Normal elderly persons should recall at least 2 words after delay (sensitivity 80%, specificity 74%). Several cutoff points were derived from normative data stratified by age and education. CONCLUSIONS: The cutoff for AD-MCI and stratified norms are available for the MoCA total score and delayed recall of the Czech version. The cut-off scores of the MoCA-CZ, sensitivity, and specificity are lower than in the original study.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dementia and Geriatric Cognitive Disorders

ISSN

1420-8008

e-ISSN

1421-9824

Svazek periodika

46

Číslo periodika v rámci svazku

5-6

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

335-345

Kód UT WoS článku

000456155700009

EID výsledku v databázi Scopus

2-s2.0-85058186835