Tractography of fornix and gyrus subcallosus and paraterminalis in patients with Alzheimer's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915380" target="_blank" >RIV/00023752:_____/16:43915380 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.konferencestarnuti.cz/files/Starnuti_2016_sbornik.pdf" target="_blank" >http://www.konferencestarnuti.cz/files/Starnuti_2016_sbornik.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tractography of fornix and gyrus subcallosus and paraterminalis in patients with Alzheimer's disease

Popis výsledku v původním jazyce

Alzheimer's disease (AD) is neurodegenerative disease characterized by extracellular, insoluble beta-amyloid plaques and intracytoplasmic tau-associated neurofibrillary tangles. This process leads to the loss of neurons and connectivity. The aim of this study was to measure parameters of fornix and gyrus subcallosus and paraterminalis in patients with AD (34) and healthy controls (34) of similar age. Probands were divided by a neurologist based on psychological and clinical examination. Difusion tensor imaging scans were acquired on 3T MRI. The area of fornix and gyrus subcallosus and paraterminalis was drawn manually according to anatomical position in all dimensions on T2 weighted MRI images. Then tractography, visualization of neural tracts, was created. We obtained these parameters: number of tracts, tract length, tract volume, quantitative anisotropy (QA) and generalized fractional anisotropy (GFA). There was statistically significant decrease of number of tracts and tract length and statistically significant increase of QA in the area of left fornix in patients with AD. Statistically significant decrease of number of tracts, tract length and GFA was also observed in the area of right fornix in patients with AD. There was an increase of number of tracts, tract volume, QA and GFA in the left and right area of gyrus subcallosus and paraterminalis in patients with AD. Fornix is a part of the limbic system associated with episodic memory, the ability to recall an event from recent or distant past. Degeneration of fornix according to DTI analysis explains long-term memory loss in patients with AD. There was significant increase in parameters in the area of gyrus subcallosus and paraterminalis, area associated with short-term memory. A higher GFA value, registered in gyrus subcallosus and paraterminalis, indicates better integrity of the neural fiber bundles which might represent the compensation of AD. Tractography could help diagnose AD.

Název v anglickém jazyce

Tractography of fornix and gyrus subcallosus and paraterminalis in patients with Alzheimer's disease

Popis výsledku anglicky

Alzheimer's disease (AD) is neurodegenerative disease characterized by extracellular, insoluble beta-amyloid plaques and intracytoplasmic tau-associated neurofibrillary tangles. This process leads to the loss of neurons and connectivity. The aim of this study was to measure parameters of fornix and gyrus subcallosus and paraterminalis in patients with AD (34) and healthy controls (34) of similar age. Probands were divided by a neurologist based on psychological and clinical examination. Difusion tensor imaging scans were acquired on 3T MRI. The area of fornix and gyrus subcallosus and paraterminalis was drawn manually according to anatomical position in all dimensions on T2 weighted MRI images. Then tractography, visualization of neural tracts, was created. We obtained these parameters: number of tracts, tract length, tract volume, quantitative anisotropy (QA) and generalized fractional anisotropy (GFA). There was statistically significant decrease of number of tracts and tract length and statistically significant increase of QA in the area of left fornix in patients with AD. Statistically significant decrease of number of tracts, tract length and GFA was also observed in the area of right fornix in patients with AD. There was an increase of number of tracts, tract volume, QA and GFA in the left and right area of gyrus subcallosus and paraterminalis in patients with AD. Fornix is a part of the limbic system associated with episodic memory, the ability to recall an event from recent or distant past. Degeneration of fornix according to DTI analysis explains long-term memory loss in patients with AD. There was significant increase in parameters in the area of gyrus subcallosus and paraterminalis, area associated with short-term memory. A higher GFA value, registered in gyrus subcallosus and paraterminalis, indicates better integrity of the neural fiber bundles which might represent the compensation of AD. Tractography could help diagnose AD.

Druh

D - Stať ve sborníku

CEP obor

AN - Psychologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Stárnutí 2016: Sborník příspěvků z 3. Gerontologické mezioborové konference

ISBN

978-80-87878-22-4

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

94-98

Název nakladatele

Univerzita Karlova. 3. lékařská fakulta

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

21. 10. 2016

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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