Tractography of fornix and gyrus subcallosus and paraterminalis in patients with Alzheimer's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000110" target="_blank" >RIV/00064173:_____/16:N0000110 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/16:43912776

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tractography of fornix and gyrus subcallosus and paraterminalis in patients with Alzheimer's disease

Popis výsledku v původním jazyce

Alzheimer's disease (AD) is neurodegenerative disease characterized by extracellular, insoluble beta-amyloid plaques and intracytoplasmic tau-associated neurofibrillary tangles. This process leads to the loss of neurons and connectivity. Diffusion tensor imaging DTI-based tractography is able to visualize neural tracts and white matter damage using the measurement of the restricted diffusion of water in tissue. Using this method and visualization we can measure DTI parameters, see neural connections and results can be used in diagnosis of AD. The aim of this study was to measure parameters of fornix and gyrus subcallosus and paratermi-nalis in patients with AD and healthy controls of similar age. Then compare results and determine statisti-cal differences between both groups. Patients with AD and controls were divided by a neurologist based on psychological and clinical examination. DTI scans were acquired on 3T MRI at Institute for Clinical and Experimental Medicine (IKEM). DSI Studio was used for QSDR image reconstruction. The area of fornix and gyrus subcallosus and paraterminalis was drawn manually according to anatomical position in all dimensions on T2 weighted MRI images. Then tractography, visualization of neural tracts, was created. Based on reconstructed neural tracts we obtained these parameters: number of tracts, tract length, tract volume, quantitative anisotropy (QA) and generalized fractional anisotropy (GFA). Statistical analysis was performed using STATISTICA 13 (t-test). We compared 34 patients with AD and 34 control patients. There was statistically significant decrease of number of tracts and tract length and statistically significant increase of QA in the area of left fornix in patients with AD.

Název v anglickém jazyce

Tractography of fornix and gyrus subcallosus and paraterminalis in patients with Alzheimer's disease

Popis výsledku anglicky

Alzheimer's disease (AD) is neurodegenerative disease characterized by extracellular, insoluble beta-amyloid plaques and intracytoplasmic tau-associated neurofibrillary tangles. This process leads to the loss of neurons and connectivity. Diffusion tensor imaging DTI-based tractography is able to visualize neural tracts and white matter damage using the measurement of the restricted diffusion of water in tissue. Using this method and visualization we can measure DTI parameters, see neural connections and results can be used in diagnosis of AD. The aim of this study was to measure parameters of fornix and gyrus subcallosus and paratermi-nalis in patients with AD and healthy controls of similar age. Then compare results and determine statisti-cal differences between both groups. Patients with AD and controls were divided by a neurologist based on psychological and clinical examination. DTI scans were acquired on 3T MRI at Institute for Clinical and Experimental Medicine (IKEM). DSI Studio was used for QSDR image reconstruction. The area of fornix and gyrus subcallosus and paraterminalis was drawn manually according to anatomical position in all dimensions on T2 weighted MRI images. Then tractography, visualization of neural tracts, was created. Based on reconstructed neural tracts we obtained these parameters: number of tracts, tract length, tract volume, quantitative anisotropy (QA) and generalized fractional anisotropy (GFA). Statistical analysis was performed using STATISTICA 13 (t-test). We compared 34 patients with AD and 34 control patients. There was statistically significant decrease of number of tracts and tract length and statistically significant increase of QA in the area of left fornix in patients with AD.

Druh

D - Stať ve sborníku

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Stárnutí 2016: Sborník příspěvků 3. gerontologické mezioborové konference

ISBN

978-80-87878-23-1

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

94-98

Název nakladatele

Univerzita Karlova, 3. lékařská fakulta

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

21. 10. 2016

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

000392695400013