The role of steroids in the prediction of affective disorders in adult men

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915346" target="_blank" >RIV/00023752:_____/17:43915346 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/17:N0000021

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0039128X16301672" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X16301672</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.steroids.2016.11.004" target="_blank" >10.1016/j.steroids.2016.11.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of steroids in the prediction of affective disorders in adult men

Popis výsledku v původním jazyce

Objective: Anxiety and mood disorders (AMD) are the most frequent mental disorders in the human population. They have recently shown increasing prevalence, and commonly disrupt personal and working lives. The aim of our study was to analyze the spectrum of circulating steroids in order to discover differences that could potentially be markers of affective depression or anxiety, and identify which steroids could be a predictive component for these diseases. Methods: We studied the steroid metabolome including 47 analytes in 20 men with depression (group D), 20 men with anxiety (group AN) and 30 healthy controls. OPLS and multivariate regression models were used for statistical analysis. Results: Discrimination of group D from controls by the OPLS method was absolute, as was group AN from controls (sensitivity = 1.000 (0.839, 1.000), specificity = 1.000 (0.887, 1.000)). Relatively good predictivity was also found for discrimination between group D from AN (sensitivity = 0.850 (0.640, 0.948), specificity = 0.900 (0.699, 0.972). Conclusion: Selected circulating steroids, including those that are neuroactive and neuroprotective, can be useful tools for discriminating between these affective diseases in adult men.

Název v anglickém jazyce

The role of steroids in the prediction of affective disorders in adult men

Popis výsledku anglicky

Objective: Anxiety and mood disorders (AMD) are the most frequent mental disorders in the human population. They have recently shown increasing prevalence, and commonly disrupt personal and working lives. The aim of our study was to analyze the spectrum of circulating steroids in order to discover differences that could potentially be markers of affective depression or anxiety, and identify which steroids could be a predictive component for these diseases. Methods: We studied the steroid metabolome including 47 analytes in 20 men with depression (group D), 20 men with anxiety (group AN) and 30 healthy controls. OPLS and multivariate regression models were used for statistical analysis. Results: Discrimination of group D from controls by the OPLS method was absolute, as was group AN from controls (sensitivity = 1.000 (0.839, 1.000), specificity = 1.000 (0.887, 1.000)). Relatively good predictivity was also found for discrimination between group D from AN (sensitivity = 0.850 (0.640, 0.948), specificity = 0.900 (0.699, 0.972). Conclusion: Selected circulating steroids, including those that are neuroactive and neuroprotective, can be useful tools for discriminating between these affective diseases in adult men.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

<a href="/cs/project/NT13890" target="_blank" >NT13890: Úloha neuroaktivních steroidů v etiopatogenezi afektivních a úzkostných poruch</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Steroids

ISSN

0039-128X

e-ISSN

—

Svazek periodika

121

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

47-53

Kód UT WoS článku

000400038500007

EID výsledku v databázi Scopus

2-s2.0-85015295871