Obesity, dyslipidemia and brain age in first-episode psychosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919327" target="_blank" >RIV/00023752:_____/18:43919327 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985807:_____/18:00488005 RIV/00216208:11120/18:43916347

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0022395617312141" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022395617312141</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpsychires.2018.02.012" target="_blank" >10.1016/j.jpsychires.2018.02.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Obesity, dyslipidemia and brain age in first-episode psychosis

Popis výsledku v původním jazyce

Introduction Obesity and dyslipidemia may negatively affect brain health and are frequent medical comorbidities of schizophrenia and related disorders. Despite the high burden of metabolic disorders, little is known about their effects on brain structure in psychosis. We investigated, whether obesity or dyslipidemia contributed to brain alterations in first-episode psychosis (FEP). Methods 120 participants with FEP, who were undergoing their first psychiatric hospitalization, had &lt;24 months of untreated psychosis and were 18–35 years old and 114 controls within the same age range participated in the study. We acquired 3T brain structural MRI, fasting lipids and body mass index. We used machine learning trained on an independent sample of 504 controls to estimate the individual brain age of study participants and calculated the BrainAGE score by subtracting the chronological from the estimated brain age. Results In a multiple regression model, the diagnosis of FEP (B = 1.15, SE B = 0.31, p &lt; 0.001) and obesity/overweight (B = 0.92, SE B = 0.35, p = 0.008) were each additively associated with BrainAGE scores (R2 = 0.22, F(3, 230) = 21.92, p &lt; 0.001). BrainAGE scores were highest in participants with FEP and obesity/overweight (3.83 years, 95%CI = 2.35-5.31) and lowest in normal weight controls (−0.27 years, 95%CI = −1.22-0.69). LDL-cholesterol, HDL-cholesterol or triglycerides were not associated with BrainAGE scores. Conclusions Overweight/obesity may be an independent risk factor for diffuse brain alterations manifesting as advanced brain age already early in the course of psychosis. These findings raise the possibility that targeting metabolic health and intervening already at the level of overweight/obesity could slow brain ageing in FEP.

Název v anglickém jazyce

Obesity, dyslipidemia and brain age in first-episode psychosis

Popis výsledku anglicky

Introduction Obesity and dyslipidemia may negatively affect brain health and are frequent medical comorbidities of schizophrenia and related disorders. Despite the high burden of metabolic disorders, little is known about their effects on brain structure in psychosis. We investigated, whether obesity or dyslipidemia contributed to brain alterations in first-episode psychosis (FEP). Methods 120 participants with FEP, who were undergoing their first psychiatric hospitalization, had &lt;24 months of untreated psychosis and were 18–35 years old and 114 controls within the same age range participated in the study. We acquired 3T brain structural MRI, fasting lipids and body mass index. We used machine learning trained on an independent sample of 504 controls to estimate the individual brain age of study participants and calculated the BrainAGE score by subtracting the chronological from the estimated brain age. Results In a multiple regression model, the diagnosis of FEP (B = 1.15, SE B = 0.31, p &lt; 0.001) and obesity/overweight (B = 0.92, SE B = 0.35, p = 0.008) were each additively associated with BrainAGE scores (R2 = 0.22, F(3, 230) = 21.92, p &lt; 0.001). BrainAGE scores were highest in participants with FEP and obesity/overweight (3.83 years, 95%CI = 2.35-5.31) and lowest in normal weight controls (−0.27 years, 95%CI = −1.22-0.69). LDL-cholesterol, HDL-cholesterol or triglycerides were not associated with BrainAGE scores. Conclusions Overweight/obesity may be an independent risk factor for diffuse brain alterations manifesting as advanced brain age already early in the course of psychosis. These findings raise the possibility that targeting metabolic health and intervening already at the level of overweight/obesity could slow brain ageing in FEP.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Psychiatric Research

ISSN

0022-3956

e-ISSN

—

Svazek periodika

99

Číslo periodika v rámci svazku

April 2018

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

151-158

Kód UT WoS článku

000429511200017

EID výsledku v databázi Scopus

2-s2.0-85042011818