Brain age in early stages of bipolar disorders or schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919191" target="_blank" >RIV/00023752:_____/19:43919191 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbx172/4767816?searchresult=1" target="_blank" >https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbx172/4767816?searchresult=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/schbul/sbx172" target="_blank" >10.1093/schbul/sbx172</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Brain age in early stages of bipolar disorders or schizophrenia

Popis výsledku v původním jazyce

BACKGROUND: The greater presence of neurodevelopmental antecedants may differentiate schizophrenia from bipolar disorders (BD). Machine learning/pattern recognition allows us to estimate the biological age of the brain from structural magnetic resonance imaging scans (MRI). The discrepancy between brain and chronological age could contribute to early detection and differentiation of BD and schizophrenia. METHODS: We estimated brain age in 2 studies focusing on early stages of schizophrenia or BD. In the first study, we recruited 43 participants with first episode of schizophrenia-spectrum disorders (FES) and 43 controls. In the second study, we included 96 offspring of bipolar parents (48 unaffected, 48 affected) and 60 controls. We used relevance vector regression trained on an independent sample of 504 controls to estimate the brain age of study participants from structural MRI. We calculated the brain-age gap estimate (BrainAGE) score by subtracting the chronological age from the brain age. RESULTS: Participants with FES had higher BrainAGE scores than controls (F(1, 83) = 8.79, corrected P = 0.008, Cohen&apos;s d = 0.64). Their brain age was on average 2.64 ± 4.15 years greater than their chronological age (matched t(42) = 4.36, P &lt; 0.001). In contrast, participants at risk or in the early stages of BD showed comparable BrainAGE scores to controls (F(2,149) = 1.04, corrected P = 0.70, η2 = 0.01) and comparable brain and chronological age. CONCLUSIONS: Early stages of schizophrenia, but not early stages of BD, were associated with advanced BrainAGE scores. Participants with FES showed neurostructural alterations, which made their brains appear 2.64 years older than their chronological age. BrainAGE scores could aid in early differential diagnosis between BD and schizophrenia.

Název v anglickém jazyce

Brain age in early stages of bipolar disorders or schizophrenia

Popis výsledku anglicky

BACKGROUND: The greater presence of neurodevelopmental antecedants may differentiate schizophrenia from bipolar disorders (BD). Machine learning/pattern recognition allows us to estimate the biological age of the brain from structural magnetic resonance imaging scans (MRI). The discrepancy between brain and chronological age could contribute to early detection and differentiation of BD and schizophrenia. METHODS: We estimated brain age in 2 studies focusing on early stages of schizophrenia or BD. In the first study, we recruited 43 participants with first episode of schizophrenia-spectrum disorders (FES) and 43 controls. In the second study, we included 96 offspring of bipolar parents (48 unaffected, 48 affected) and 60 controls. We used relevance vector regression trained on an independent sample of 504 controls to estimate the brain age of study participants from structural MRI. We calculated the brain-age gap estimate (BrainAGE) score by subtracting the chronological age from the brain age. RESULTS: Participants with FES had higher BrainAGE scores than controls (F(1, 83) = 8.79, corrected P = 0.008, Cohen&apos;s d = 0.64). Their brain age was on average 2.64 ± 4.15 years greater than their chronological age (matched t(42) = 4.36, P &lt; 0.001). In contrast, participants at risk or in the early stages of BD showed comparable BrainAGE scores to controls (F(2,149) = 1.04, corrected P = 0.70, η2 = 0.01) and comparable brain and chronological age. CONCLUSIONS: Early stages of schizophrenia, but not early stages of BD, were associated with advanced BrainAGE scores. Participants with FES showed neurostructural alterations, which made their brains appear 2.64 years older than their chronological age. BrainAGE scores could aid in early differential diagnosis between BD and schizophrenia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Schizophrenia Bulletin

ISSN

0586-7614

e-ISSN

—

Svazek periodika

45

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

190-198

Kód UT WoS článku

000461523000024

EID výsledku v databázi Scopus

2-s2.0-85058883008