Asymmetric changes in limbic cortex and planum temporale in patients with Alzheimer disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919513" target="_blank" >RIV/00023752:_____/18:43919513 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/18:43917154

Výsledek na webu

<a href="http://www.eurekaselect.com/165953/article" target="_blank" >http://www.eurekaselect.com/165953/article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1567205015666181004142659" target="_blank" >10.2174/1567205015666181004142659</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Asymmetric changes in limbic cortex and planum temporale in patients with Alzheimer disease

Popis výsledku v původním jazyce

There are several cortical areas related to the limbic system that form the output from the hippocampal formation whose cellular and morphological features are important for the onset and progression of AD. We hypothesized that there would be a significant difference in the size of cortical pyramidal neurons and that there would also be a hemispheric asymmetry between Alzheimer disease patients and controls. These differences would potentially be accompanied by an increase in the numbers of Fluoro-Jade B-positive degenerating cortical neurons and a corresponding decrease in the number of DAPI-stained cortical neuronal nuclei in subjects with AD compared to controls. Such changes could potentially be used as another marker in postmortem neuropathological diagnosis of AD.

Název v anglickém jazyce

Asymmetric changes in limbic cortex and planum temporale in patients with Alzheimer disease

Popis výsledku anglicky

There are several cortical areas related to the limbic system that form the output from the hippocampal formation whose cellular and morphological features are important for the onset and progression of AD. We hypothesized that there would be a significant difference in the size of cortical pyramidal neurons and that there would also be a hemispheric asymmetry between Alzheimer disease patients and controls. These differences would potentially be accompanied by an increase in the numbers of Fluoro-Jade B-positive degenerating cortical neurons and a corresponding decrease in the number of DAPI-stained cortical neuronal nuclei in subjects with AD compared to controls. Such changes could potentially be used as another marker in postmortem neuropathological diagnosis of AD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Alzheimer Research

ISSN

1567-2050

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

1361-1368

Kód UT WoS článku

000457594500009

EID výsledku v databázi Scopus

2-s2.0-85056584202