Near‐fatal Intoxication with the “New” Synthetic Opioid U‐47700: the first reported case in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919692" target="_blank" >RIV/00023752:_____/19:43919692 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10394282 RIV/00216208:11130/19:10394282 RIV/00216208:11310/19:10394282 RIV/00064203:_____/19:10394282 RIV/00064165:_____/19:10394282

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/1556-4029.13903" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/1556-4029.13903</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1556-4029.13903" target="_blank" >10.1111/1556-4029.13903</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Near‐fatal Intoxication with the “New” Synthetic Opioid U‐47700: the first reported case in the Czech Republic

Popis výsledku v původním jazyce

Recreational use of the potent synthetic opioid 3,4‐ dichloro‐N‐(2‐(dimethylamino)cyclohexyl)‐N‐methylbenzamide (U‐47700) is rising, accompanied by increasingly frequent cases of serious intoxication. This article reports a case of near‐fatal U‐47700 intoxication. A man was found unconscious (with drug powder residues). After 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged. Liquid chromatography/high‐resolution mass spectrometry (LC/HRMS) or gas chromatography/mass spectrometry (GC/MS) were used to detect and quantify substances in powders, serum and urine. Powders contained U‐47700 and two synthetic cannabinoids. Serum and urine were positive for U‐47700 (351.0 ng/mL), citalopram (&lt;LOQ), tetrahydrocannabinol (THC: 3.3 ng/mL), midazolam (&lt;LOQ) and a novel benzodiazepine, clonazolam (6.8 ng/mL) and their metabolites but negative for synthetic cannabinoids. If potent synthetic opioids become cheaper and more easily obtainable than their classical counterparts (e.g., heroin), they will inevitably replace them and users may be exposed to elevated risks of addiction and overdose.

Název v anglickém jazyce

Near‐fatal Intoxication with the “New” Synthetic Opioid U‐47700: the first reported case in the Czech Republic

Popis výsledku anglicky

Recreational use of the potent synthetic opioid 3,4‐ dichloro‐N‐(2‐(dimethylamino)cyclohexyl)‐N‐methylbenzamide (U‐47700) is rising, accompanied by increasingly frequent cases of serious intoxication. This article reports a case of near‐fatal U‐47700 intoxication. A man was found unconscious (with drug powder residues). After 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged. Liquid chromatography/high‐resolution mass spectrometry (LC/HRMS) or gas chromatography/mass spectrometry (GC/MS) were used to detect and quantify substances in powders, serum and urine. Powders contained U‐47700 and two synthetic cannabinoids. Serum and urine were positive for U‐47700 (351.0 ng/mL), citalopram (&lt;LOQ), tetrahydrocannabinol (THC: 3.3 ng/mL), midazolam (&lt;LOQ) and a novel benzodiazepine, clonazolam (6.8 ng/mL) and their metabolites but negative for synthetic cannabinoids. If potent synthetic opioids become cheaper and more easily obtainable than their classical counterparts (e.g., heroin), they will inevitably replace them and users may be exposed to elevated risks of addiction and overdose.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Forensic Sciences

ISSN

0022-1198

e-ISSN

—

Svazek periodika

64

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

647-650

Kód UT WoS článku

000460187200041

EID výsledku v databázi Scopus

2-s2.0-85053490845