Brain volumes and their ratios in Alzheimer´s disease on magnetic resonance imaging segmented using Freesurfer 6.0

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919808" target="_blank" >RIV/00023752:_____/19:43919808 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/19:43918082 RIV/00064173:_____/19:N0000010 RIV/00023001:_____/19:00077983

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0925492718302324?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0925492718302324?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pscychresns.2019.01.014" target="_blank" >10.1016/j.pscychresns.2019.01.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Brain volumes and their ratios in Alzheimer´s disease on magnetic resonance imaging segmented using Freesurfer 6.0

Popis výsledku v původním jazyce

Ratios between opposing volumes from brain magnetic resonance imaging (MRI) can provide additional information to volumes in Alzheimer&apos;s disease (AD). Brain three-dimensional MPRAGE MRI at 3T were segmented into 44 regions using FreeSurfer v6 in 75 participants. The region&apos;s size in absolute volumes and relative proportions to the whole brain volume were compared between 39 AD patients and 36 age-, education- and sex-matched normal controls (NC). Volumes of the most atrophied parts were related to the opposing volumes of the most enlarged parts as ratios. The most atrophic structures in AD were both hippocampi. By contrast, the greatest enlargements in AD were inferior parts of both lateral ventricles. The best ratio for each side was the hippocampo-horn proportion calculated as ratio: the hippocampus / (the hippocampus + inferior lateral ventricle). Its optimal cut-off of 74% yielded sensitivity of 74% and specificity of 78% on the left and sensitivity of 74% and specificity of 78% on the right. The hippocampo-horn proportion is another measure to evaluate the degree of hippocampal atrophy on brain MRI in percentages. It has a potential to be simplified into a comparison of two-dimensional corresponding areas or a visual assessment.

Název v anglickém jazyce

Brain volumes and their ratios in Alzheimer´s disease on magnetic resonance imaging segmented using Freesurfer 6.0

Popis výsledku anglicky

Ratios between opposing volumes from brain magnetic resonance imaging (MRI) can provide additional information to volumes in Alzheimer&apos;s disease (AD). Brain three-dimensional MPRAGE MRI at 3T were segmented into 44 regions using FreeSurfer v6 in 75 participants. The region&apos;s size in absolute volumes and relative proportions to the whole brain volume were compared between 39 AD patients and 36 age-, education- and sex-matched normal controls (NC). Volumes of the most atrophied parts were related to the opposing volumes of the most enlarged parts as ratios. The most atrophic structures in AD were both hippocampi. By contrast, the greatest enlargements in AD were inferior parts of both lateral ventricles. The best ratio for each side was the hippocampo-horn proportion calculated as ratio: the hippocampus / (the hippocampus + inferior lateral ventricle). Its optimal cut-off of 74% yielded sensitivity of 74% and specificity of 78% on the left and sensitivity of 74% and specificity of 78% on the right. The hippocampo-horn proportion is another measure to evaluate the degree of hippocampal atrophy on brain MRI in percentages. It has a potential to be simplified into a comparison of two-dimensional corresponding areas or a visual assessment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatry Research-Neuroimaging

ISSN

0925-4927

e-ISSN

—

Svazek periodika

287

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

70-74

Kód UT WoS článku

000465073700010

EID výsledku v databázi Scopus

2-s2.0-85064160244