Evolutionary origins of chemical synapses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F20%3A43920245" target="_blank" >RIV/00023752:_____/20:43920245 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0083672920300339?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0083672920300339?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/bs.vh.2020.04.009" target="_blank" >10.1016/bs.vh.2020.04.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evolutionary origins of chemical synapses

Popis výsledku v původním jazyce

Synaptic transmission is a fundamental neurobiological process by which neurons interact with each other and non-neuronal cells. The process enables release of active substances from the presynaptic neuron onto receptive elements of postsynaptic cells, inducing waves of spreading excitation. While much has been learned about the cellular and molecular mechanisms enabling and governing transmitter release and sensing, the evolutionary origin of synaptic connections remains obscure. Herein, we review emerging evidence and concepts suggesting that key components of chemical synapses arose independently, in different functional and biological contexts, before the rise of neurons and multicellular living forms. We argue that throughout evolution, distinct synaptic constituents have been co-opted from ancestral forms for a new role in early metazoans, leading to the rise of current chemical synapses and neurotransmission. Such an eclectic model of the origin of chemical synapses agrees with and supports the pluralistic hypothesis of evolutionary change.

Název v anglickém jazyce

Evolutionary origins of chemical synapses

Popis výsledku anglicky

Synaptic transmission is a fundamental neurobiological process by which neurons interact with each other and non-neuronal cells. The process enables release of active substances from the presynaptic neuron onto receptive elements of postsynaptic cells, inducing waves of spreading excitation. While much has been learned about the cellular and molecular mechanisms enabling and governing transmitter release and sensing, the evolutionary origin of synaptic connections remains obscure. Herein, we review emerging evidence and concepts suggesting that key components of chemical synapses arose independently, in different functional and biological contexts, before the rise of neurons and multicellular living forms. We argue that throughout evolution, distinct synaptic constituents have been co-opted from ancestral forms for a new role in early metazoans, leading to the rise of current chemical synapses and neurotransmission. Such an eclectic model of the origin of chemical synapses agrees with and supports the pluralistic hypothesis of evolutionary change.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

50103 - Cognitive sciences

Projekt

<a href="/cs/project/LO1611" target="_blank" >LO1611: Udržitelnost pro Národní ústav duševního zdraví</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Vitamins and Hormones

ISSN

0083-6729

e-ISSN

—

Svazek periodika

114

Číslo periodika v rámci svazku

2020

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

21

Strana od-do

1-21

Kód UT WoS článku

000612641100002

EID výsledku v databázi Scopus

2-s2.0-85087395425